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Effects of chemoradiation therapy by using capecitabine on gastric cancer patients

Date:
September 20, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Singapore reviewed the outcome of patients with resected gastric cancers treated with capecitabine and radiation compared to 5-fluorouracil with radiation or fluoropyrimidine-based chemotherapy only. They found that survival of patients treated with capecitabine and radiation was comparable to the other two conventional treatments.

Gastric cancer is a major cause of cancer deaths in the world. The outcome of large gastric tumors and those with lymph node involvement remains poor after surgical resection. The optimal adjuvant therapy after surgical resection remains to be determined. The most common strategies in the adjuvant treatment of gastric cancers include fluoropyrimidine-based chemotherapy with or without radiation. The introduction of capecitabine has largely replaced continuous-infusion 5-fluorouracil (5-FU) owing to its ease of administration. However, its efficacy is not proven in randomized phase III trials involving gastric cancers.

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A research article published on August 7, 2010 in the World Journal of Gastroenterology addresses this question. In this retrospective review study, the authors examined the role of capecitabine with radiation and compared its efficacy to the 5-FU with radiation regimen and fluoropyrimidinebased chemotherapy alone.

This study showed that capecitabine with concurrent radiation was as effective as 5-FU with radiation or fluoropyrimidine-based chemotherapy alone without radiation when given as adjuvant treatment for locally advanced gastric cancer.

The result from this hypothesis-generating study provides the basis for a further prospective study in evaluating the role of radiation with concurrent capecitabine as adjuvant therapy in resected gastric cancers.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tham CK, Choo SP, Poon DYH, Toh HC, Ong SYK, Tan SH, Wang MLC, Foo KF. Capecitabine with radiation is an effective adjuvant therapy in gastric cancers. World Journal of Gastroenterology, 2010; 16 (29): 3709 DOI: 10.3748/wjg.v16.i29.3709

Cite This Page:

World Journal of Gastroenterology. "Effects of chemoradiation therapy by using capecitabine on gastric cancer patients." ScienceDaily. ScienceDaily, 20 September 2010. <www.sciencedaily.com/releases/2010/09/100920111340.htm>.
World Journal of Gastroenterology. (2010, September 20). Effects of chemoradiation therapy by using capecitabine on gastric cancer patients. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2010/09/100920111340.htm
World Journal of Gastroenterology. "Effects of chemoradiation therapy by using capecitabine on gastric cancer patients." ScienceDaily. www.sciencedaily.com/releases/2010/09/100920111340.htm (accessed January 28, 2015).

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