Featured Research

from universities, journals, and other organizations

Umbilical cord blood not suitable for assessing allergy risk

Date:
October 6, 2010
Source:
University of Copenhagen
Summary:
For years, hospitals and researchers have been testing blood samples from the umbilical cords of newborn babies to assess the risk of allergy. Now a study has revealed that the biomarker in the blood that indicates the risk factor for allergy often comes from the mother rather than her baby.

For years, hospitals and researchers have been testing blood samples from the umbilical cords of newborn babies to assess the risk of allergy. Now a study has revealed that the biomarker in the blood that indicates the risk factor for allergy often comes from the mother rather than her baby.

Cord blood has been used to indicate allergy risk

Allergies occur when the defence mechanisms of the immune system malfunction and misread normal substances entering the body as invading pathogens. Antibodies are part of our biochemical arsenal for combating viruses, bacteria, parasites and other alien substances, but during an allergic reaction the antibody, known as IgE, is directed against usually harmless substances such as grass pollen, nuts, pets or eggs. Asthma and allergies are chronic diseases that reduce quality of life and pose an economic burden on society.

New parents have therefore previously been asked if they would like hospitals to assess the risk their babies run of developing allergies in childhood. Hospitals tests the risk by measuring the amount of IgE in the blood of the umbilical cord. The results are then used to determine the need for allergy prophylaxis, e.g. whether babies need a special allergy-friendly milk substitute.

The Biomarker originates from the mother

However, researchers from COPSAC (Copenhagen Studies on Asthma in Childhood) at the Faculty of Health Sciences, University of Copenhagen recently discovered indications that IgE in the blood of the umbilical cord could originate from the mother, and decided to conduct a focused study on this.

They measured the total amount if IgE in the blood of the umbilical cord in 243 new-borns. The researchers subsequently determined how much IgE originated from the mother by using hypersensitive analyses of IgE in the blood of the umbilical cord, blood from the mother, and blood from the baby six months after birth.

"We discovered that approximately half of the tests with increased IgE levels in the umbilical blood were due to IgE from the mother," Dr. Klaus B๘nnelykke, PhD says. "This may explain why many studies have shown poor results from the use of umbilical cord IgE. In future, if we want to use blood from the umbilical cord to assess the risk of an infant developing asthma or allergy we need to take the transfer of IgE from the mother into account. Or we will need to find another method."

The discovery has been published in the Journal of Allergy and Clinical Immunology.


Story Source:

The above story is based on materials provided by University of Copenhagen. Note: Materials may be edited for content and length.


Journal Reference:

  1. Klaus B๘nnelykke, Christian Bressen Pipper, Hans Bisgaard. Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood. Journal of Allergy and Clinical Immunology, 2010; 126 (3): 657 DOI: 10.1016/j.jaci.2010.06.027

Cite This Page:

University of Copenhagen. "Umbilical cord blood not suitable for assessing allergy risk." ScienceDaily. ScienceDaily, 6 October 2010. <www.sciencedaily.com/releases/2010/10/101005104442.htm>.
University of Copenhagen. (2010, October 6). Umbilical cord blood not suitable for assessing allergy risk. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2010/10/101005104442.htm
University of Copenhagen. "Umbilical cord blood not suitable for assessing allergy risk." ScienceDaily. www.sciencedaily.com/releases/2010/10/101005104442.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins