Featured Research

from universities, journals, and other organizations

Finasteride reduces symptoms and disease progression associated with enlarged prostates, study finds

Date:
October 6, 2010
Source:
Wiley-Blackwell
Summary:
When compared with placebo and other drugs, long-term use of finasteride improves urinary tract symptoms associated with benign prostatic hyperplasia, and reduces disease progression. This conclusion comes from combining the findings of 23 randomized clinical trials that evaluated almost 21,000 men.

When compared with placebo and other drugs, long-term use of finasteride improves urinary tract symptoms associated with benign prostatic hyperplasia, and reduces disease progression. This conclusion comes from combining the findings of 23 randomized clinical trials that evaluated almost 21,000 men, and is published this month in The Cochrane Library.

Finasteride is frequently given to men who have lower urinary tract symptoms (LUTS) such as frequent voiding at night (nocturia), incomplete emptying, hesitancy, weak stream, and frequent and urgent urination. The symptoms are often caused by prostatic smooth-muscle contractions, and by benign prostatic hyperplasia, a non-cancerous condition in which the prostate gland grows too large.

Like many organs in the body, the size of the prostate is influenced by particular hormones. Dihydrotestosterone is one hormone that increases its size. Finasteride belongs to a class of drugs called 5 alpha reductase inhibitors (5ARI) that reduce prostate size. The full effects of how 5ARIs shrink the prostate are not fully understood, but in part they work by blocking the body's ability to make dihydrotestosterone.

Pharmacologic therapy is the most frequent way of treating men with moderate to severe LUTS and related symptoms. Drugs like finasteride are frequently prescribed to improve LUTS and reduce long-term symptom progression, including the risk for acute urinary retention and the need for surgical intervention. "We needed to determine the effectiveness and harms of finasteride when used on its own or in combination with other therapies, and to compare this with similar drugs," says study leader James Tacklind, who works at the Veterans Affairs Medical Center, Minneapolis, USA.

Finasteride was even more effective at lowering symptom scores when used in combination with doxazosin, an alpha blocker.

"Finasteride seems to be more effective in men with large prostates who use the drugs for at least 1 year, compared to those with small prostates," says Tacklind.

Looking at drug-related adverse effects, the researchers found that they were uncommon in men using finasteride; nevertheless, compared to placebo, men taking it are at slightly increased risk for impotence, erectile dysfunction, decreased libido, and ejaculation disorder.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. James Tacklind, Howard A Fink, Roderick MacDonald, Indy Rutks, Timothy J Wilt. Finasteride for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews, 2010 (10): CD006015 DOI: 10.1002/14651858.CD006015.pub3

Cite This Page:

Wiley-Blackwell. "Finasteride reduces symptoms and disease progression associated with enlarged prostates, study finds." ScienceDaily. ScienceDaily, 6 October 2010. <www.sciencedaily.com/releases/2010/10/101006085236.htm>.
Wiley-Blackwell. (2010, October 6). Finasteride reduces symptoms and disease progression associated with enlarged prostates, study finds. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/10/101006085236.htm
Wiley-Blackwell. "Finasteride reduces symptoms and disease progression associated with enlarged prostates, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/10/101006085236.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins