Featured Research

from universities, journals, and other organizations

Low-dose exposure to chemical warfare agent may result in long-term heart damage

Date:
October 14, 2010
Source:
American Heart Association
Summary:
New research found that the pattern of heart dysfunction with sarin exposure in mice resembles that seen in humans. Sarin is a chemical warfare agent belonging to class of compounds called organophosphates -- the basis for insecticides, herbicides and nerve agents.

New research has found that the pattern of heart dysfunction with sarin exposure in mice resembles that seen in humans. Sarin is a chemical warfare agent belonging to class of compounds called organophosphates -- the basis for insecticides, herbicides and nerve agents. As an inhibitor of the nervous system enzyme acetylcholinesterase, sarin can cause convulsions, stoppage of breathing and death.

Aiming to determine the delayed cardiac effects of sarin, researchers studied mice injected with sarin -- at doses too low to produce visible symptoms -- 10 weeks after the exposure.

"The two-month period was used to simulate the late onset effect of sarin/nerve agents in gulf war veterans," said Mariana Morris, director of the research program. "There are suggestions that gulf war illness; in which symptoms are long-lasting, may be related to exposure to low-dose chemical warfare agents."

Cardiac damage detected in sarin-exposed mice at 10 weeks, but not earlier, included:

  • Left ventricular dilation, meaning the heart's left ventricle is larger.
  • Prolonged ventricular repolarization, an electrical conduction anomaly that could lead to heart rhythm abnormalities.
  • Reduction in contractility, the extent of ventricular contraction and hence the amount of blood pumped from the ventricle when it contracts.

"These results have implications for the military in times of conflict and for civilian populations in cases of environmental or occupational exposure," Morris said.

The research is being presented at the American Heart Association's High Blood Pressure Research 2010 Scientific Sessions, being held in Washington, D.C., Oct. 13-16, 2010.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Low-dose exposure to chemical warfare agent may result in long-term heart damage." ScienceDaily. ScienceDaily, 14 October 2010. <www.sciencedaily.com/releases/2010/10/101013164705.htm>.
American Heart Association. (2010, October 14). Low-dose exposure to chemical warfare agent may result in long-term heart damage. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2010/10/101013164705.htm
American Heart Association. "Low-dose exposure to chemical warfare agent may result in long-term heart damage." ScienceDaily. www.sciencedaily.com/releases/2010/10/101013164705.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins