Featured Research

from universities, journals, and other organizations

Low-dose exposure to chemical warfare agent may result in long-term heart damage

Date:
October 14, 2010
Source:
American Heart Association
Summary:
New research found that the pattern of heart dysfunction with sarin exposure in mice resembles that seen in humans. Sarin is a chemical warfare agent belonging to class of compounds called organophosphates -- the basis for insecticides, herbicides and nerve agents.

New research has found that the pattern of heart dysfunction with sarin exposure in mice resembles that seen in humans. Sarin is a chemical warfare agent belonging to class of compounds called organophosphates -- the basis for insecticides, herbicides and nerve agents. As an inhibitor of the nervous system enzyme acetylcholinesterase, sarin can cause convulsions, stoppage of breathing and death.

Related Articles


Aiming to determine the delayed cardiac effects of sarin, researchers studied mice injected with sarin -- at doses too low to produce visible symptoms -- 10 weeks after the exposure.

"The two-month period was used to simulate the late onset effect of sarin/nerve agents in gulf war veterans," said Mariana Morris, director of the research program. "There are suggestions that gulf war illness; in which symptoms are long-lasting, may be related to exposure to low-dose chemical warfare agents."

Cardiac damage detected in sarin-exposed mice at 10 weeks, but not earlier, included:

  • Left ventricular dilation, meaning the heart's left ventricle is larger.
  • Prolonged ventricular repolarization, an electrical conduction anomaly that could lead to heart rhythm abnormalities.
  • Reduction in contractility, the extent of ventricular contraction and hence the amount of blood pumped from the ventricle when it contracts.

"These results have implications for the military in times of conflict and for civilian populations in cases of environmental or occupational exposure," Morris said.

The research is being presented at the American Heart Association's High Blood Pressure Research 2010 Scientific Sessions, being held in Washington, D.C., Oct. 13-16, 2010.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Low-dose exposure to chemical warfare agent may result in long-term heart damage." ScienceDaily. ScienceDaily, 14 October 2010. <www.sciencedaily.com/releases/2010/10/101013164705.htm>.
American Heart Association. (2010, October 14). Low-dose exposure to chemical warfare agent may result in long-term heart damage. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2010/10/101013164705.htm
American Heart Association. "Low-dose exposure to chemical warfare agent may result in long-term heart damage." ScienceDaily. www.sciencedaily.com/releases/2010/10/101013164705.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins