Featured Research

from universities, journals, and other organizations

Study reveals superior sedation method for children

Date:
October 19, 2010
Source:
University of Western Ontario
Summary:
Procedural sedation and analgesia is an essential element of care for children requiring painful procedures in the emergency department. New research provides evidence that when compared to ketamine alone, patients who receive a combination of ketamine and propofol have a slightly faster recovery time and suffer from less severe side effects.

Procedural sedation and analgesia is an essential element of care for children requiring painful procedures in the emergency department. The practice of combining ketamine and propofol, two common medications used in emergency departments, has become more popular. However, until recently, it was unclear whether this practice was superior to the use of either agent alone, especially in children.

Research led by Drs. Amit Shah, Gregory Mosdossy and Michael Rieder of the Schulich School of Medicine & Dentistry at The University of Western Ontario and Lawson Health Research Institute provides evidence that when compared to ketamine alone, patients who receive a combination of ketamine and propofol have a slightly faster recovery time and suffer from less severe side effects.

The study, published online in the Annals of Emergency Medicine, included 136 children treated at London Health Sciences Centre's Children's Hospital.

Ketamine is well established as a safe and effective solitary agent for procedural sedation and analgesia. However, it is known to cause adverse side effects, such as vomiting. Propofol is associated with a dose-dependent risk of respiratory depression, but has less severe side effects.

It has been theorized that by combining the two agents, you can decrease the dose requirement of both agents thereby reducing the negative side-effects, but still have a safe and effective analgesia.

This is the first large well-conducted study exploring the use of ketamine-propofol for children in the Paediatric Emergency Department. Previous studies had hinted at its advantage but up until now results were not conclusive.

"Our study found that ketamine-propofol is an effective combination for pediatric procedural sedation, providing a slightly shorter total sedation time than ketamine alone, with less adverse events and higher satisfaction scores," says Dr. Shah. "We believe this study provides evidence for a safe and effective alternative sedation regimen for children in the Emergency Department and may lead to a change in sedation practices in other hospitals."


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amit Shah, Gregory Mosdossy, Shelley McLeod, Kris Lehnhardt, Michael Peddle, Michael Rieder. A Blinded, Randomized Controlled Trial to Evaluate Ketamine-Propofol Versus Ketamine Alone for Procedural Sedation in Children. Annals of Emergency Medicine, 2010; DOI: 10.1016/j.annemergmed.2010.08.032

Cite This Page:

University of Western Ontario. "Study reveals superior sedation method for children." ScienceDaily. ScienceDaily, 19 October 2010. <www.sciencedaily.com/releases/2010/10/101019152612.htm>.
University of Western Ontario. (2010, October 19). Study reveals superior sedation method for children. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/10/101019152612.htm
University of Western Ontario. "Study reveals superior sedation method for children." ScienceDaily. www.sciencedaily.com/releases/2010/10/101019152612.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins