Featured Research

from universities, journals, and other organizations

Real-time imaging of stroke models

Date:
October 22, 2010
Source:
Optical Society of America
Summary:
One of the major impediments to understanding how brain cells die during a stroke and identifying new ways to protect them has been the long-standing inability to image strokes, or "ischemic events" in living tissue. Now researchers have developed methods to induce strokes in animal models and image the events as they unfold.

One of the major impediments to understanding how brain cells die during a stroke and identifying new ways to protect them has been the long-standing inability to image strokes, or "ischemic events" in living tissue. Now researchers at Cornell University, led by Research Associate Nozomi Nishimura, have developed methods to induce strokes in animal models and image the events as they unfold.

Related Articles


"We can see the dynamics of interaction," Nishimura says, adding that some neurons most likely die due to interactions with many different types of cells, including immune system cells, vascular cells, astrocytes and glial cells. She and her colleagues visualize intercellular dynamics via two-photon excited fluorescence (2PEF) microscopy, which is able to image individual cells and capillaries. Employing relatively long wavelengths of light, Nishimura and her colleagues have succeeded in imaging at greater depths into tissue than has been possible to date.

Nishimura and her colleagues have also developed a method to induce localized lesions within rodent models. They adapted a technology, femtosecond laser ablation, typically used in micromachining of solid materials, for a novel biological use. This ability to induce specific small lesions is particularly important to creating viable models in which to study the progression typical of dementia. According to Nishimura, it is becoming clear that many elderly people suffering from dementia have experienced a series of microstrokes, triggering cumulative damage. "How is it that these small bleeds or blood clots affect neurons?" she asks, adding that the ability to introduce and then image microstrokes in a model system should shed light on how damage might best be mitigated.

The laser ablation system is also being explored for use in surgical manipulation and in examining tumor migration, specifically, how cells shed from tumors might also block blood vessels.

The presentation, "Nonlinear Optical Tools for Studying Small-Stroke at Microscopic Scales," takes place on Oct. 26 at the Frontiers in Optics (FiO) 2010/Laser Science XXVI -- the 94th annual meeting of the Optical Society (OSA), which is being held together with the annual meeting of the American Physical Society (APS) Division of Laser Science at the Rochester Riverside Convention Center in Rochester, N.Y., from Oct. 24-28.


Story Source:

The above story is based on materials provided by Optical Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Optical Society of America. "Real-time imaging of stroke models." ScienceDaily. ScienceDaily, 22 October 2010. <www.sciencedaily.com/releases/2010/10/101020195215.htm>.
Optical Society of America. (2010, October 22). Real-time imaging of stroke models. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2010/10/101020195215.htm
Optical Society of America. "Real-time imaging of stroke models." ScienceDaily. www.sciencedaily.com/releases/2010/10/101020195215.htm (accessed October 26, 2014).

Share This



More Matter & Energy News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
Real-Life Transformer Robot Walks, Then Folds Into a Car

Real-Life Transformer Robot Walks, Then Folds Into a Car

Buzz60 (Oct. 24, 2014) Brave Robotics and Asratec teamed with original Transformers toy company Tomy to create a functional 5-foot-tall humanoid robot that can march and fold itself into a 3-foot-long sports car. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Police Testing New Gunfire Tracking Technology

Police Testing New Gunfire Tracking Technology

AP (Oct. 24, 2014) A California-based startup has designed new law enforcement technology that aims to automatically alert dispatch when an officer's gun is unholstered and fired. Two law enforcement agencies are currently testing the technology. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins