Featured Research

from universities, journals, and other organizations

Heavy smoking in midlife may be associated with dementia in later years

Date:
October 26, 2010
Source:
JAMA and Archives Journals
Summary:
Heavy smoking in middle age appears to be associated with more than double the risk for Alzheimer's disease and other forms of dementia two decades later, according to a new study.

New research finds that heavy smoking in middle age appears to be associated with more than double the risk for Alzheimer's disease and other forms of dementia two decades later.
Credit: iStockphoto/Mark Fairey

Heavy smoking in middle age appears to be associated with more than double the risk for Alzheimer's disease and other forms of dementia two decades later, according to a report posted online that will be published in the February 28 print issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Related Articles


Current estimates suggest smoking is responsible for several million deaths per year from causes such as heart disease and cancer, according to background information in the article. Although smoking increases risks of most diseases and of death, some studies have shown a reduced risk of Parkinson's disease and other neurodegenerative conditions among smokers. "The link between smoking and risk of Alzheimer's disease, the most common subtype of dementia, has been somewhat controversial, with some studies suggesting that smoking reduces the risk of cognitive impairment," the authors write.

Minna Rusanen, M.D., of University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, and colleagues analyzed data from 21,123 members of one health care system who participated in a survey between 1978 and 1985, when they were 50 to 60 years old. Diagnoses of dementia, Alzheimer's disease and vascular dementia were tracked from Jan. 1, 1994 (when participants were an average of 71.6 years old), through July 31, 2008.

A total of 5,367 participants (25.4 percent) were diagnosed with dementia during an average of 23 years of follow-up, including 1,136 with Alzheimer's disease and 416 with vascular dementia. Those who smoked more than two packs per day in middle age had an elevated risk of dementia overall and also of each subtype, Alzheimer's disease and vascular dementia, compared with non-smokers. Former smokers, or those who smoked less than half a pack per day, did not appear to be at increased risk.

Associations between smoking and dementia did not vary by race or sex. Smoking is a well-established risk factor for stroke, and may contribute to the risk of vascular dementia through similar mechanisms, the authors note. In addition, smoking contributes to oxidative stress and inflammation, believed to be important in the development of Alzheimer's disease. "It is possible that smoking affects the development of dementia via vascular and neurodegenerative pathways," the authors write.

"To our knowledge, this is the first study evaluating the amount of midlife smoking on long-term risk of dementia and dementia subtypes in a large multiethnic cohort," they conclude. "Our study suggests that heavy smoking in middle age increases the risk of both Alzheimer's disease and vascular dementia for men and women across different race groups. The large detrimental impact that smoking already has on public health has the potential to become even greater as the population worldwide ages and dementia prevalence increases."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Minna Rusanen; Miia Kivipelto; Charles P. Quesenberry, Jr; Jufen Zhou; Rachel A. Whitmer. Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia. Archives of Internal Medicine, 2010; DOI: 10.1001/archinternmed.2010.393

Cite This Page:

JAMA and Archives Journals. "Heavy smoking in midlife may be associated with dementia in later years." ScienceDaily. ScienceDaily, 26 October 2010. <www.sciencedaily.com/releases/2010/10/101025161034.htm>.
JAMA and Archives Journals. (2010, October 26). Heavy smoking in midlife may be associated with dementia in later years. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2010/10/101025161034.htm
JAMA and Archives Journals. "Heavy smoking in midlife may be associated with dementia in later years." ScienceDaily. www.sciencedaily.com/releases/2010/10/101025161034.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com
1st Responders Trained for Autism Sensitivity

1st Responders Trained for Autism Sensitivity

AP (Dec. 16, 2014) More departments are ordering their first responders to sit in on training sessions that focus on how to more effectively interact with those with autism spectrum disorder (Dec. 16) Video provided by AP
Powered by NewsLook.com
Guys Are Idiots, According To Sarcastic Study

Guys Are Idiots, According To Sarcastic Study

Newsy (Dec. 12, 2014) A study out of Britain suggest men are more idiotic than women based on the rate of accidental deaths and other factors. Video provided by Newsy
Powered by NewsLook.com
Believing in Father Christmas Good for Children's Imaginations

Believing in Father Christmas Good for Children's Imaginations

AFP (Dec. 12, 2014) As the countdown to Christmas gets underway, so too does the Father Christmas conspiracy. But psychologists say that telling our children about Santa, flying reindeer and elves is good for their imaginations. Duration: 01:57 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins