Featured Research

from universities, journals, and other organizations

Lactate in the brain reveals aging process

Date:
November 2, 2010
Source:
Karolinska Institutet
Summary:
Researchers may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic acid levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator of aging and age-related diseases of the central nervous system.

Researchers at Karolinska Institutet have shown that they may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic acid levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator of aging and age-related diseases of the central nervous system.

"It's exciting to think that we are one step closer to understanding what happens as the brain ages, and how a change of brain metabolism may be important during the onset of age-related changes and diseases," says Professor Lars Olson, who lead the study.

The research group used both prematurely and normally aging mice to investigate the relationship between damage to mitochondria -- the organelle responsible for energy production in the cell -- and changes in metabolism during the aging process. Previous studies have shown a link between mitochondrial dysfunction and age-related neurodegenerative disorders, such as Parkinson's and Alzheimer´s disease.

In the current study, which is published in the Proceedings of the National Academy of Sciences, the researchers show that the damage to the mitochondria slowly increases with age in brains of mice and causes altered expression in certain genes that are responsible for the formation of lactate. They also show that brain lactate levels may increase in advance of other indices of aging, and can be detected using non-invasive magnetic resonance imaging techniques.

"Our study was conducted in mice, but the same technique can be used in humans," says Lars Olson. "So there is hope that one day physicians might be able to give your brain a check-up and help determine its age by using MRI."

In addition to Lars Olson's research group at Karolinska Institutet, scientists from the US, Germany and the UK took part in the study. The group will now continue its search for new knowledge, trying to understand the role of high lactate in the brain.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jaime M. Ross, Johanna Öberg, Stefan Brené, Giuseppe Coppotelli, Mügen Terzioglu, Karin Pernold, Michel Goiny, Rouslan Sitnikov, Jan Kehr, Aleksandra Trifunovic, Nils-Göran Larsson, Barry J. Hoffer, Lars Olson. High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1008189107

Cite This Page:

Karolinska Institutet. "Lactate in the brain reveals aging process." ScienceDaily. ScienceDaily, 2 November 2010. <www.sciencedaily.com/releases/2010/11/101102083646.htm>.
Karolinska Institutet. (2010, November 2). Lactate in the brain reveals aging process. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/11/101102083646.htm
Karolinska Institutet. "Lactate in the brain reveals aging process." ScienceDaily. www.sciencedaily.com/releases/2010/11/101102083646.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) — Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins