Featured Research

from universities, journals, and other organizations

Protecting against vascular dementia after stroke

Date:
November 8, 2010
Source:
King's College London
Summary:
The preservation of a protein found in particular synapses in the brain plays a key role in protecting against vascular dementia after a stroke, say researchers.

The preservation of a protein found in particular synapses in the brain plays a key role in protecting against vascular dementia after a stroke, say researchers at King's College London.

The study, funded by the Dunhill Medical Trust, is published in the November issue of Neurology, the medical journal of the American Academy of Neurology. Researchers say the study findings increase understanding of vascular dementia, and highlight a possible target for future diagnoses and treatment of the condition.

Professor Paul Francis, King's College London, said: 'Vascular dementia accounts for 15 to 20 per cent of the 25 million people worldwide with dementia, yet there is currently no effective treatment. It is common for people to develop vascular dementia after suffering a stroke, which can be devastating for patients and their carers.

'Understanding the chemical processes that affect the brain when people develop vascular dementia is a vital step towards identifying potential treatments for this common condition. The findings of this study take us that little bit closer towards achieving this goal.'

Vascular dementia, the second most common form of the condition, is caused by problems in the supply of blood to the brain, such as a stroke, and can affect memory, thinking, behaviour and the ability to perform everyday activities. One in three older people who have a stroke develop dementia within three months, with a 10-fold increased risk of dementia over five years.

The team, led by Professor Paul Francis at King's in collaboration with Newcastle University, studied differences in nerves and synapses in the brain tissue of individuals with and without dementia, over half of which had also suffered a stroke previously.

A synapse is a tiny gap between two neurones (nerve cells) in the brain, and information is transported across this gap by a neurotransmitter. Synapses that use glutamate (an amino acid) as a neurotransmitter are known to be related to memory and cognition, and contain a protein called VGLUT1.

The autopsy study specifically looked at the levels of VGLUT1 by analysing brain tissue from 73 individuals, obtained from the Brains for Dementia Research programme. Forty-seven individuals had a form of cerebrovascular disease, triggered when the blood supply to the brain is disturbed in some way, such as a stroke. Twenty-seven of these people had undergone an annual cognition test in the years before their death as part of the Cambridge Assessment of Mental Health for the Elderly (CAMCOG) evaluation.

The findings show a correlation between levels of VGLUT1 and cognition scores -- the higher the concentration of VGLUT1, the better they did in the CAMCOG cognition assessment.

Crucially, the study also showed that in those individuals who did not develop dementia after a stroke, the levels of VGLUT1 were significantly higher.

These findings suggest that if levels of VGLUT1 can be preserved artificially after a stroke, the chances of developing vascular dementia could be significantly reduced.


Story Source:

The above story is based on materials provided by King's College London. Note: Materials may be edited for content and length.


Cite This Page:

King's College London. "Protecting against vascular dementia after stroke." ScienceDaily. ScienceDaily, 8 November 2010. <www.sciencedaily.com/releases/2010/11/101108161216.htm>.
King's College London. (2010, November 8). Protecting against vascular dementia after stroke. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/11/101108161216.htm
King's College London. "Protecting against vascular dementia after stroke." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108161216.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins