Featured Research

from universities, journals, and other organizations

Imaging procedure can identify biomarker associated with Alzheimer's disease

Date:
January 26, 2011
Source:
JAMA and Archives Journals
Summary:
Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, a biomarker that is identified during autopsy to confirm a diagnosis of Alzheimer's disease, according to a new study.

Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, a biomarker that is identified during autopsy to confirm a diagnosis of Alzheimer disease, according to a study in the January 19 issue of JAMA.

Related Articles


"Both diagnosis and treatment of Alzheimer disease (AD) are hampered by the lack of noninvasive biomarkers of the underlying pathology. Between 10 percent and 20 percent of patients clinically diagnosed with AD lack AD pathology at autopsy, and community physicians may not diagnose AD in 33 percent of patients with mild signs and symptoms," according to background information in the article. "The ability to identify and quantify brain beta-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease." Several types of positron emission tomographic (PET) imaging tests are under study, with florbetapir F 18 (a diagnostic chemical that binds with beta-amyloid) PET showing promise. "However, the definitive relationship between the florbetapir-PET image and beta-amyloid deposition has not been established."

Christopher M. Clark, M.D., of Avid Radiopharmaceuticals, Philadelphia, and colleagues conducted a study to determine if florbetapir F 18 PET imaging performed during life accurately predicts the presence of beta-amyloid in the brain at autopsy. Florbetapir-PET imaging was performed on 35 patients from hospice, long-term care, and community health care facilities near the end of their lives (6 patients to establish the protocol and 29 to validate), which was compared with measures of brain beta-amyloid that was determined by autopsy after their death. PET images were also obtained in 74 young individuals (18-50 years) presumed free of brain amyloid to better understand the frequency of a false-positive interpretation of a florbetapir-PET image.

Florbetapir-PET imaging was performed an average of 99 days before death for the 29 individuals in the primary analysis group. Fifteen of the 29 individuals (51.7 percent) met pathological criteria for AD. Analysis of images and other data indicated a correlation between florbetapir-PET images and presence and quantity of beta-amyloid pathology at autopsy. "Florbetapir-PET images and postmortem results rated as positive or negative for beta-amyloid agreed in 96 percent of the 29 individuals in the primary analysis cohort. The florbetapir-PET image was rated as amyloid negative in the 74 younger individuals in the nonautopsy cohort," the researchers write.

They add that while amyloid pathology is an essential element for an AD diagnosis, "clinically impaired function may depend, in part, on the ability of the individual's brain to tolerate aggregated amyloid. Genetic risk factors, lifestyle choices, environmental factors, and neuropathological comorbidities may alter the threshold for the onset of cognitive impairment associated with beta-amyloid aggregation."

"This prospective imaging to autopsy study provides evidence that a molecular imaging procedure can identify beta-amyloid pathology in the brains of individuals during life. Understanding the appropriate use of florbetapir-PET imaging in the clinical diagnosis of AD or in the prediction of progression to dementia will require additional studies," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher M. Clark, Julie A. Schneider, Barry J. Bedell, Thomas G. Beach, Warren B. Bilker, Mark A. Mintun, Michael J. Pontecorvo, Franz Hefti, Alan P. Carpenter, Matthew L. Flitter, Michael J. Krautkramer, Hank F. Kung, R. Edward Coleman, P. Murali Doraiswamy, Adam S. Fleisher, Marwan N. Sabbagh, Carl H. Sadowsky, P. Eric M. Reiman, Simone P. Zehntner, Daniel M. Skovronsky, for the AV45-A07 Study Group. Use of Florbetapir-PET for Imaging β-Amyloid Pathology. JAMA, 2011; 305 (3): 275-283 DOI: 10.1001/jama.2010.2008

Cite This Page:

JAMA and Archives Journals. "Imaging procedure can identify biomarker associated with Alzheimer's disease." ScienceDaily. ScienceDaily, 26 January 2011. <www.sciencedaily.com/releases/2011/01/110118161407.htm>.
JAMA and Archives Journals. (2011, January 26). Imaging procedure can identify biomarker associated with Alzheimer's disease. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/01/110118161407.htm
JAMA and Archives Journals. "Imaging procedure can identify biomarker associated with Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118161407.htm (accessed October 25, 2014).

Share This



More Mind & Brain News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins