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Medication dosing errors for infants and children

Date:
January 25, 2011
Source:
Canadian Medical Association Journal
Summary:
Preparing small doses of medication from syringes may be inaccurate and can result in crucial dosing errors for infants and children, according to a new study.

Preparing small doses of medication from syringes may be inaccurate and can result in crucial dosing errors for infants and children, according to a study published in CMAJ (Canadian Medical Association Journal).

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Because babies and young children require small doses of drugs, these are often prepared from stock of less than 0.1 mL which can result in dosing errors and possible adverse events. Medications most commonly requiring small doses include potent narcotics and sedatives such as morphine, lorazepam and fentanyl as well as immunosuppressants.

"The safe administration of medications requires formulations that permit accurate preparation and administration," writes Dr. Christopher Parshuram, Department of Paediatrics, The Hospital for Sick Children (SickKids) and Director of Paediatric Patient Safety Research, University of Toronto Centre for Patient Safety, with coauthors. "Current equipment does not permit the accurate measurement of volumes less than 0.1 mL."

The researchers conducted a theoretical study as well as a clinical study of 1531 patients admitted to the ICU in 2006. Out of 71 218 intravenous doses, 5245 (7.4%) needed preparations of less than 0.1 mL of stock solution and 12 439 (17.5%) needed preparations from less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," write the authors. "Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions. The clinical sequelae of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

The authors conclude that since this practice occurs in paediatric hospitals across North America, the "re-evaluation of preparation methods, regulatory requirements and manufacturing practices is warranted."


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Navjeet Uppal, Baseer Yasseen, Winnie Seto, Christopher S. Parshuram. Drug formulations that require potentially inaccurate volumes to prepare doses for infants and children. CMAJ, Jan 24, 2011 DOI: 10.1503 /cmaj.100467

Cite This Page:

Canadian Medical Association Journal. "Medication dosing errors for infants and children." ScienceDaily. ScienceDaily, 25 January 2011. <www.sciencedaily.com/releases/2011/01/110124121541.htm>.
Canadian Medical Association Journal. (2011, January 25). Medication dosing errors for infants and children. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2011/01/110124121541.htm
Canadian Medical Association Journal. "Medication dosing errors for infants and children." ScienceDaily. www.sciencedaily.com/releases/2011/01/110124121541.htm (accessed March 4, 2015).

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