Featured Research

from universities, journals, and other organizations

Medication dosing errors for infants and children

Date:
January 25, 2011
Source:
Canadian Medical Association Journal
Summary:
Preparing small doses of medication from syringes may be inaccurate and can result in crucial dosing errors for infants and children, according to a new study.

Preparing small doses of medication from syringes may be inaccurate and can result in crucial dosing errors for infants and children, according to a study published in CMAJ (Canadian Medical Association Journal).

Related Articles


Because babies and young children require small doses of drugs, these are often prepared from stock of less than 0.1 mL which can result in dosing errors and possible adverse events. Medications most commonly requiring small doses include potent narcotics and sedatives such as morphine, lorazepam and fentanyl as well as immunosuppressants.

"The safe administration of medications requires formulations that permit accurate preparation and administration," writes Dr. Christopher Parshuram, Department of Paediatrics, The Hospital for Sick Children (SickKids) and Director of Paediatric Patient Safety Research, University of Toronto Centre for Patient Safety, with coauthors. "Current equipment does not permit the accurate measurement of volumes less than 0.1 mL."

The researchers conducted a theoretical study as well as a clinical study of 1531 patients admitted to the ICU in 2006. Out of 71 218 intravenous doses, 5245 (7.4%) needed preparations of less than 0.1 mL of stock solution and 12 439 (17.5%) needed preparations from less than 0.2 mL.

"Our findings indicate a substantial source of dosing error that involved potent medications and affected more than a quarter of the children studied," write the authors. "Small volumes of stock solution are required because of the relatively low doses needed for infants and young children and the relatively high concentrations of commercially available stock solutions. The clinical sequelae of errors occurring as a result of preparing doses from small volumes will be compounded by incomplete safety data, errors in medication orders, and errors in preparation or administration."

The authors conclude that since this practice occurs in paediatric hospitals across North America, the "re-evaluation of preparation methods, regulatory requirements and manufacturing practices is warranted."


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Navjeet Uppal, Baseer Yasseen, Winnie Seto, Christopher S. Parshuram. Drug formulations that require potentially inaccurate volumes to prepare doses for infants and children. CMAJ, Jan 24, 2011 DOI: 10.1503 /cmaj.100467

Cite This Page:

Canadian Medical Association Journal. "Medication dosing errors for infants and children." ScienceDaily. ScienceDaily, 25 January 2011. <www.sciencedaily.com/releases/2011/01/110124121541.htm>.
Canadian Medical Association Journal. (2011, January 25). Medication dosing errors for infants and children. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2011/01/110124121541.htm
Canadian Medical Association Journal. "Medication dosing errors for infants and children." ScienceDaily. www.sciencedaily.com/releases/2011/01/110124121541.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins