Featured Research

from universities, journals, and other organizations

Hearing with your nose: How nasal stem cells could tackle childhood hearing problems

Date:
February 16, 2011
Source:
Wiley-Blackwell
Summary:
Stem cell scientists have found that patients suffering from hearing problems which began during infancy and childhood could benefit from a transplant of stem cells from their nose. The research reveals that mucosa-derived stem cells can help preserve hearing function during the early-onset of sensorineural hearing loss.

Stem cell scientists in Australia have found that patients suffering from hearing problems which began during infancy and childhood could benefit from a transplant of stem cells from their nose. The research, published February 9 in the journal Stem Cells reveals that mucosa-derived stem cells can help preserve hearing function during the early-onset of sensorineural hearing loss.

Sensorineural hearing loss is caused by the loss of sensory cells or neurons in the cochlea, the sensory organ of the inner ear responsible for hearing. The condition can have genetic causes, often arising during infancy and childhood, hindering cognitive development and leading to speech and language problems.

"One of the challenges in tackling this condition is that the regenerative ability of the human cochlea is severely limited," said lead author Dr. Sharon Oleskevich from the Hearing Research Group at The University of New South Wales. "It has been proposed that the transplantation of cells from other parts of the body could treat, prevent or even reverse hearing loss. The transplanted cells have the potential to repair tissue by replacing damaged cells and enhancing the survival of existing cells, preventing the condition from developing further."

To investigate the effects of this treatment, nasal stem cells were injected into the cochlea of mice displaying symptoms of hearing loss. Mice were chosen for this treatment as they display a similar decline in hearing function following infancy.

"The authors have used an interesting type of adult stem cell, related to mesenchymal stem cells, to reduce the extent of hearing loss. Since the cells did not integrate into the cochlea, it is likely that the effects from the adult stem cells were due to the release of factors to preserve function of the endogenous stem cells. Mesenchymal stem cells are known to provide factors to keep many types of cells healthy and functioning," said Jan Nolta, Associate Editor of Stem Cells.

Patient hearing levels were examined using the auditory brainstem response assay, which determines the lowest sound level to which the brain responds, known as the hearing threshold.

The mice which received the transplanted cells were compared to mice who had not received the treatment a month later, revealing that the hearing threshold level in stem cell-transplanted mice was significantly lower.

"The results demonstrate a significant effect of nasal stem cell transplantations for sensorineural hearing loss," concluded Oleskevich. "These cells can be obtained easily from the nasal cavity making this transplantation a potential treatment for other human conditions including Parkinson's disease and cardiac infarction."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sonali R. Pandit, Jeremy M. Sullivan, Viktoria Egger, Alexander A. Borecki, Sharon Oleskevich. Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss. Stem Cells, 2011; DOI: 10.1002/stem.609

Cite This Page:

Wiley-Blackwell. "Hearing with your nose: How nasal stem cells could tackle childhood hearing problems." ScienceDaily. ScienceDaily, 16 February 2011. <www.sciencedaily.com/releases/2011/02/110209204819.htm>.
Wiley-Blackwell. (2011, February 16). Hearing with your nose: How nasal stem cells could tackle childhood hearing problems. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/02/110209204819.htm
Wiley-Blackwell. "Hearing with your nose: How nasal stem cells could tackle childhood hearing problems." ScienceDaily. www.sciencedaily.com/releases/2011/02/110209204819.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins