Featured Research

from universities, journals, and other organizations

New drug treatment possibilities for Alzheimer's

Date:
February 11, 2011
Source:
University of California - Santa Barbara
Summary:
Scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer's disease and type 2 diabetes.

This is a piece of the Alzheimer's peptide.
Credit: Bowers and the Buratto Groups, UCSB

UC Santa Barbara scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer's disease and Type 2 diabetes.

Related Articles


The amyloid diseases are characterized by plaque that aggregates into toxic agents that interact with cellular machinery, explained Michael T. Bowers, lead author and professor in the Department of Chemistry and Biochemistry. Other amyloid diseases include Parkinson's disease, Huntington's disease, and atherosclerosis. Amyloid plaques are protein fibrils that, in the case of Alzheimer's disease, develop prior to the appearance of symptoms.

"The systems we use are model systems, but the results are groundbreaking," said Bowers. He explained that his research provides the first examples of the conversion of randomly assembled aggregates of small peptides into ordered beta sheets that comprise fibrils. Fibrils are the final structural state of the aggregation process.

Their work is published in a recent issue of Nature Chemistry. In the article, Bowers describes how understanding the fundamental forces that relate aggregation, shape, and biochemistry of soluble peptide aggregates is central to developing diagnostic and therapeutic strategies for amyloid diseases.

Bowers and his research team used a method called ion-mobility spectrometry-mass spectrometry (IMS-MS). This method enabled the team to deduce the peptide self-assembly method. They then examined a series of amyloid-forming peptides clipped from larger peptides or proteins associated with disease.

Bowers explained that IMS-MS has the potential to open new avenues for investigating the pathogenic mechanisms of amyloid diseases, their early diagnosis and eventual treatment.

The first author of the paper is Christian Blieholder, a Humbolt Postdoctoral Fellow at UCSB. Thomas Wyttenbach, UCSB associate researcher, is a co-author. Nicholas F. Dupuis, who was a Ph.D. student at UCSB at the time of the research, is also a co-author; he is now a postdoctoral fellow at the University of Colorado.


Story Source:

The above story is based on materials provided by University of California - Santa Barbara. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christian Bleiholder, Nicholas F. Dupuis, Thomas Wyttenbach, Michael T. Bowers. Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation. Nature Chemistry, 2010; 3 (2): 172 DOI: 10.1038/nchem.945

Cite This Page:

University of California - Santa Barbara. "New drug treatment possibilities for Alzheimer's." ScienceDaily. ScienceDaily, 11 February 2011. <www.sciencedaily.com/releases/2011/02/110210141245.htm>.
University of California - Santa Barbara. (2011, February 11). New drug treatment possibilities for Alzheimer's. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2011/02/110210141245.htm
University of California - Santa Barbara. "New drug treatment possibilities for Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2011/02/110210141245.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins