Featured Research

from universities, journals, and other organizations

Metastasis: Extracellular matrix tugging creates 'come hither' stimulus for cancer migration

Date:
March 31, 2011
Source:
Wayne State University - Office of the Vice President for Research
Summary:
Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited. One researcher, however, is expanding the scientific understanding of what makes malignant tumors spread, and the answer lies within the dense, fibrous matrix that surrounds cancer cells.

Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited. A Wayne State University researcher, however, is expanding the scientific understanding of what makes malignant tumors spread, and the answer lies within the dense, fibrous matrix that surrounds cancer cells.

Related Articles


Karen A. Beningo, Ph.D., assistant professor of biology in WSU's College of Liberal Arts and Sciences and resident of Plymouth, Mich., has found that the continuous restructuring of the extracellular matrix that upholds the weight of a tumor is one of the reasons highly invasive, malignant tumors are mechanically able to spread to other parts of the body. Beningo's study was recently published in PLoS ONE.

"This study has identified a novel physical parameter and a new conceptual framework in which to assess the process of invasion, not just of cancer cells but other invasive cell types as well," said Beningo.

Beningo simulated the tugging and pulling forces by embedding magnetic microbeads in the collagen matrix of a three-dimensional, cell-based assay. This way, she was able to examine the physical mechanisms "without the complication of secreted biochemical factors," she said.

"Surprisingly, we found that cancer cells were two to four times more likely to invade if the matrix was magnetically stimulated than if the culture was not stimulated," said Beningo.

She also found that less invasive tumors were not as stimulated by the tugging and pulling forces of the extracellular matrix as highly invasive tumors. Moreover, the absence of fibronectin, a component of the extracellular matrix, and cofilin, a cellular protein, removed the tumor's sensitivity to the mechanical "come hither" stimulus.

"We can conclusively state that fibronectin and cofilin are required for this mechanical response," said Beningo.

Beningo is working toward defining the mechanism of mechanically enhanced invasion and hopes to identify therapeutic targets.

"If we can prevent the invasive movement of cancer cells from the primary tumor, a large battle in the war on cancer will have been won," she said.

Financial support for the study was provided by Wayne State University.


Story Source:

The above story is based on materials provided by Wayne State University - Office of the Vice President for Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shalini Menon, Karen A. Beningo. Cancer Cell Invasion Is Enhanced by Applied Mechanical Stimulation. PLoS ONE, 2011; 6 (2): e17277 DOI: 10.1371/journal.pone.0017277

Cite This Page:

Wayne State University - Office of the Vice President for Research. "Metastasis: Extracellular matrix tugging creates 'come hither' stimulus for cancer migration." ScienceDaily. ScienceDaily, 31 March 2011. <www.sciencedaily.com/releases/2011/03/110322151412.htm>.
Wayne State University - Office of the Vice President for Research. (2011, March 31). Metastasis: Extracellular matrix tugging creates 'come hither' stimulus for cancer migration. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2011/03/110322151412.htm
Wayne State University - Office of the Vice President for Research. "Metastasis: Extracellular matrix tugging creates 'come hither' stimulus for cancer migration." ScienceDaily. www.sciencedaily.com/releases/2011/03/110322151412.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins