Featured Research

from universities, journals, and other organizations

Therapeutically promising new findings for combating hypertension and cardiovascular disease

Date:
April 16, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
Researchers have discovered a promising new avenue they strongly believe can be further developed to treat hypertension and cardiovascular disease.

More than one-third of the world's population suffers from hypertension (commonly known as high blood pressure) and cardiovascular disease (disorders that affect the heart and/or blood vessels). The U.S. Agency for Healthcare Quality and Research has reported that Americans spent $29 billion for non-prescription cardiovascular drugs alone in 2008. With the number of individuals afflicted on the rise, and the costs for treatment on the increase, scientists and policymakers are looking for new approaches to combat these disorders.

A team of Wisconsin and Texas scientific researchers have discovered a promising new avenue they strongly believe can be further developed to treat the diseases. The researchers are Md Abdul Hye Khan, William B. Campbell and John D. Imig of the Medical College of Wisconsin, Milwaukee, and Vijaya L. Manthati, Jawahar L. Jat, and John R. Falck of the University of Texas Southwestern Medical Center, Dallas.

Drs. Khan and Imig will discuss the team's findings based on their research paper, "Novel Epoxyeicosatrienoic Acid Analogs Increase Sodium Excretion and Lower Blood Pressure in Hypertension," at the 2011 Experimental Biology meeting (EB 2011), being held April 9-13, 2011 at the Washington, DC Convention Center.

Two EET Analogs Found to Lower Blood Pressure, Reduce Kidney Injury

Key to the research is the role of endothelial cells, which line the narrow spaces of the body such as those inside the blood vessels and the heart. Endothelial cells produce arachidonic acid metabolites, a class of fatty acids that have biological actions that are beneficial for cardiovascular health. This production occurs through three primary enzymatic pathways. Two of these pathways, the cyclooxygenase and the lipoxygenase pathways, have been successfully targeted for the treatment of inflammation, pain, fever, and asthma.

The third enzymatic pathway is the cytochrome P450 pathway that produces epoxyeicosatrienoic acids (EETs) as major biologically active metabolites. EETs are endothelial-derived factors that significantly influence cardiovascular function. They can dilate blood vessels, lower blood pressure and have additional biologic actions including anti-inflammatory and anti-platelet aggregator activity. These biological activities have made EETs a very attractive therapeutic target for cardiovascular diseases.

For the last several years the research team has developed and synthesized an array of EET analogs, or chemical compounds that act as EETs. The EET analogs have been tested for beneficial cardiovascular actions. For this research study 35 different EET analogs were screened for their ability to dilate blood vessels. The screening produced five EET analogs that would be further examined to determine their ability to lower blood pressure in animal models of hypertension. Two of the five EET analogs administered to hypertensive animals effectively lowered blood pressure and reduced kidney injury.

Next Steps

According to Dr. Imig, "This work is a major step forward in obtaining our goal to develop novel EET analogs for the treatment of cardiovascular disease." He added, "We strongly believe that these EET analogs are therapeutically promising and can be further developed as a novel treatment for hypertension and cardiovascular disease."

The next steps, according to Dr. Imig, are to test the EET analogs in other cardiovascular diseases and improve EET analog formulation for potential future use in humans.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Therapeutically promising new findings for combating hypertension and cardiovascular disease." ScienceDaily. ScienceDaily, 16 April 2011. <www.sciencedaily.com/releases/2011/04/110411131346.htm>.
Federation of American Societies for Experimental Biology. (2011, April 16). Therapeutically promising new findings for combating hypertension and cardiovascular disease. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2011/04/110411131346.htm
Federation of American Societies for Experimental Biology. "Therapeutically promising new findings for combating hypertension and cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411131346.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) — Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) — The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) — A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) — All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins