Featured Research

from universities, journals, and other organizations

Estrogen treatment with no side effects in sight, Swedish researchers find

Date:
April 12, 2011
Source:
University of Gothenburg
Summary:
Estrogen treatment for osteoporosis has often been associated with serious side effects. Researchers in Sweden have now, in mice, found a way of utilizing the positive effects of estrogen in mice so that only the skeleton is acted on.

Estrogen treatment for osteoporosis has often been associated with serious side effects. Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have now, in mice, found a way of utilizing the positive effects of estrogen in mice so that only the skeleton is acted on, current research at the Academy shows.

The study is presented in the Proceedings of the National Academy of Sciences.

Many women are affected by osteoporosis after the menopause, when the body's production of estrogen decreases. Estrogen is the hormone that principally strengthens the bone mass in women, and it is also of significance for the skeleton in men. Treatment of osteoporosis with estrogens is, however, associated with serious side effects such as breast cancer and blood clots. In order to develop an estrogen treatment that utilizes the favorable effects of the estrogen but not its side effects, the researchers have analyzed which parts of the estrogen receptor is most important in enabling estrogen to act on bone tissue and other tissues.

Estrogen has recipient molecules known as estrogen receptors, which cause the body to respond to estrogen.

"This is the first study to analyze the significance of different parts of a particular type of estrogen receptor through studies in mice. It enables us to differentiate the favorable effects of estrogen in bone tissue from the adverse effects in other tissues," says Anna Bφrjesson, a PhD student at the Centre for Bone and Arthritis Research at the Sahlgrenska Academy.

This knowledge improves the prospects of being able to develop new, safer estrogen treatments in the future.

"The development of special estrogens that are tailored to bone and only affect a particular part of this type of estrogen receptor may lead to a more targeted and effective treatment for osteoporosis with minimal side effects," Professor Claes Ohlsson explains.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. E. Borjesson, S. H. Windahl, M. K. Lagerquist, C. Engdahl, B. Frenkel, S. Moverare-Skrtic, K. Sjogren, J. M. Kindblom, A. Stubelius, U. Islander, M. C. Antal, A. Krust, P. Chambon, C. Ohlsson. Roles of transactivating functions 1 and 2 of estrogen receptor-α  in bone. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1100454108

Cite This Page:

University of Gothenburg. "Estrogen treatment with no side effects in sight, Swedish researchers find." ScienceDaily. ScienceDaily, 12 April 2011. <www.sciencedaily.com/releases/2011/04/110411163910.htm>.
University of Gothenburg. (2011, April 12). Estrogen treatment with no side effects in sight, Swedish researchers find. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2011/04/110411163910.htm
University of Gothenburg. "Estrogen treatment with no side effects in sight, Swedish researchers find." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411163910.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins