Featured Research

from universities, journals, and other organizations

Drug potency: What happens in space?

Date:
April 14, 2011
Source:
Springer Science+Business Media
Summary:
Some of the pharmaceuticals intended for the treatment of minor illnesses of astronauts in space may require special packaging and reformulation to remain stable for long periods in the space environment. That's according to a new study that suggests that some of the pharmaceuticals stored on space flights may have shorter shelf-life than they do on Earth.

Some of the pharmaceuticals intended for the treatment of minor illnesses of astronauts in space may require special packaging and reformulation to remain stable for long periods in the space environment. That's according to Dr. Putcha and her colleagues from NASA's Johnson Space Center. Their findings, published online in The AAPS Journal, suggest that some of the pharmaceuticals stored on space flights may have shorter shelf-life than they do on Earth.

Pharmaceuticals used on space flights are packed and dispensed in special flight-certified containers and stored in compact flight kits. They may be exposed to the unique environmental factors of space missions such as radiation and excessive vibration in addition to variations in temperature and humidity.

Scientists at the Johnson Space Center investigated whether pharmaceuticals undergo degradation in space and, if so, which environmental variables in space may affect the stability of the medications in space. They compared physical and chemical changes in 35 formulations contained in identical pharmaceutical kits stowed on the International Space Station (ISS) and on Earth.

After stowage for 28 months in space, they found that a higher percentage of the medications from each flight kit had a lower active pharmaceutical content than the controls on the ground. They also saw no variation in the temperature or humidity levels between Earth and in space.

Putcha and her colleagues suggest that exposure to the chronic low dose of ionizing radiation as well as repackaging of solid medications may be contributing factors for pharmaceutical stability in space.

The authors conclude: "It is important to characterize space-specific degradation products and toxicity limits using ground-based analogue environments of space that include proton and heavy ion radiation, vibration and multiple gravity conditions. This information can facilitate research for the development of space-hardy pharmaceuticals and packaging technologies."


Story Source:

The above story is based on materials provided by Springer Science+Business Media. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brian Du, Vernie R. Daniels, Zalman Vaksman, Jason L. Boyd, Camille Crady, Lakshmi Putcha. Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions. The AAPS Journal, 2011; DOI: 10.1208/s12248-011-9270-0

Cite This Page:

Springer Science+Business Media. "Drug potency: What happens in space?." ScienceDaily. ScienceDaily, 14 April 2011. <www.sciencedaily.com/releases/2011/04/110414065128.htm>.
Springer Science+Business Media. (2011, April 14). Drug potency: What happens in space?. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2011/04/110414065128.htm
Springer Science+Business Media. "Drug potency: What happens in space?." ScienceDaily. www.sciencedaily.com/releases/2011/04/110414065128.htm (accessed August 23, 2014).

Share This




More Space & Time News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Did Russia Really Find Plankton On The ISS? NASA Not So Sure

Did Russia Really Find Plankton On The ISS? NASA Not So Sure

Newsy (Aug. 21, 2014) Russian cosmonauts say they've found evidence of sea plankton on the International Space Station's windows. NASA is a little more skeptical. Video provided by Newsy
Powered by NewsLook.com
Space to Ground: Hello Georges

Space to Ground: Hello Georges

NASA (Aug. 18, 2014) Europe's ATV-5 delivers new science and the crew tests smart SPHERES. Questions or comments? Use #spacetoground to talk to us. Video provided by NASA
Powered by NewsLook.com
Tiny Satellites, Like The One Tossed From ISS, On The Rise

Tiny Satellites, Like The One Tossed From ISS, On The Rise

Newsy (Aug. 18, 2014) The Chasqui I, hand-delivered into orbit by a Russian cosmonaut, is one of hundreds of small satellites set to go up in the next few years. Video provided by Newsy
Powered by NewsLook.com
This Week @ NASA, August 15, 2014

This Week @ NASA, August 15, 2014

NASA (Aug. 15, 2014) Carbon Observatory’s First Data, ATV-5 Delivers Cargo, Cygnus Departs Station and more... Video provided by NASA
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins