Featured Research

from universities, journals, and other organizations

Antibody response may lead to narrowed arteries and organ rejection

Date:
April 15, 2011
Source:
American Society of Nephrology
Summary:
Kidney transplant recipients who develop antibodies in response to receiving new organs can develop accelerated arteriosclerosis, or narrowing of the arteries that supply blood to the kidney, according to a new study. The results indicate that arteriosclerosis resulting from such donor-specific antibodies may play an important role in organ rejection following transplantation.

Kidney transplant recipients who develop antibodies in response to receiving new organs can develop accelerated arteriosclerosis, or narrowing of the arteries that supply blood to the kidney, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results indicate that arteriosclerosis resulting from such donor-specific antibodies may play an important role in organ rejection following transplantation.

Antibody-mediated transplant rejection -- a process that occurs when a transplant recipient mounts antibodies against a new organ -- can contribute to declining function and ultimately loss of transplanted kidneys. To study the effects of antibody-mediated transplant rejection, Gary Hill, MD (Hôpital Européen Georges Pompidou, APHP, in Paris, France), Alexandre Loupy, MD, PhD (Hôpital Necker, APHP in Paris, France), and their colleagues examined kidney biopsies from 40 transplant patients who mounted antibodies directed against their transplanted kidney and 59 patients who did not.

The investigators found that narrowing of the arteries significantly progressed between three and 12 months after transplant in the antibody-positive patients but not in the antibody-negative patients. In those patients who did not develop antibodies, narrowing of the arteries progressed at approximately one third the rate of patients who did develop antibodies.

In the antibody-positive patients, narrowing of the arteries in the transplanted kidneys was much worse than expected based on the donor's age and translated to approximately 28 years of "aging" in the first year after transplantation. "This accelerated arteriosclerosis can now be seen to form part of the rejection process, and it will probably be found to contribute to the ultimate decline of kidney function," said Dr. Hill.

The study's results should spark considerable interest in the importance of arteriosclerosis following kidney transplantation. "Acceleration of arteriosclerosis was a totally unexpected finding, an important one since it broadens our thinking about what constitutes transplant rejection," said Dr. Hill.

Study co-authors (all in Paris, France) include Dominique Nochy, MD; Patrick Bruneval, MD; J. P. Duong van Huyen, MD, PhD (Hôpital Européen Georges Pompidou, APHP and Université Paris Descartes); Denis Glotz, MD, PhD; Caroline Suberbielle, MD, PhD (Hôpital Saint Louis, APHP); Julien Zuber, MD, PhD; Dany Anglicheau, MD, PhD; Christophe Legendre, MD (Université Paris Descartes and Hôpital Necker, APHP); Jean-Philippe Empana, MD (INSERM, U970, Paris Cardiovascular Research Center-PAARC); and Alexandre Loupy, MD, PhD (Université Paris Descartes; Hôpital Necker, APHP; and INSERM, U970, Paris Cardiovascular Research Center-PAARC).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gary Hill and Alexandre Loupy et al. Donor-Specific Antibodies Accelerate Arteriosclerosis after Kidney Transplantation. Journal of the American Society Nephrology, April 14, 2011 DOI: 10.1681/ASN.2010070777

Cite This Page:

American Society of Nephrology. "Antibody response may lead to narrowed arteries and organ rejection." ScienceDaily. ScienceDaily, 15 April 2011. <www.sciencedaily.com/releases/2011/04/110414183014.htm>.
American Society of Nephrology. (2011, April 15). Antibody response may lead to narrowed arteries and organ rejection. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2011/04/110414183014.htm
American Society of Nephrology. "Antibody response may lead to narrowed arteries and organ rejection." ScienceDaily. www.sciencedaily.com/releases/2011/04/110414183014.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) — Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) — Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins