Featured Research

from universities, journals, and other organizations

Heart failure patients' osteoporosis often undiagnosed, untreated

Date:
May 15, 2011
Source:
American Heart Association
Summary:
One in 10 heart failure patients had compression fractures in the spine that could have been detected by a chest X-ray, but few are receiving treatment to help prevent such fractures, according to a Canadian study.

One in 10 heart failure patients had compression fractures in the spine that could have been detected by a chest X-ray, but few are receiving treatment to help prevent such fractures, according to a Canadian study published in the American Heart Association journal Circulation: Heart Failure.

Among 623 heart failure patients, researchers found that 12 percent had moderate to severe vertebral compression fractures and 55 percent of those had multiple fractures. These fractures are a sign of osteoporosis, a condition in which bones become less dense and have a high risk of breaking. Only 15 percent of the heart failure patients with spinal fractures were being treated for osteoporosis, despite having a higher risk for fractures.

After adjusting for other risk factors for osteoporosis, heart failure patients who also had atrial fibrillation were twice as likely to have vertebral fractures as those with normal heart rhythms.

"Osteoporosis is an infrequently recognized and undertreated comorbidity of heart failure," said Kristin J. Lyons, M.D., C.M., lead author of the study and chief medical resident in the Department of Medicine at the University of Alberta in Edmonton, Canada. "Fortunately, the chest X-ray can be used as a case-finding tool to increase fracture identification."

Physicians' attention to the chest X-ray findings of their heart failure patients are key, said Justin A. Ezekowitz, M.D., senior author of the study and assistant professor at the Mazankowski Alberta Heart Institute in the University of Alberta in Edmonton. "While reviewing chest X-rays to look at the heart and lungs, physicians also need to look carefully at the bones. If fractures are found, patients need to be treated with dietary modification, exercise and, if indicated, osteoporosis medications. Treatment can reduce future fractures by as much as 50 percent."

Participants in the study were average age 69, 32 percent were 75 years or older and 31 percent were women. Average left ventricular ejection fraction was 32 percent in about half, 38 percent had atrial fibrillation and 65 percent had ischemic cardiomyopathy.

Heart failure patients with spinal fractures were older, more likely to be female, weighed less and more likely to have atrial fibrillation, the researchers found.

"As the population ages, two of the most prevalent diseases are heart disease and osteoporosis," Ezekowitz said. "While hip fractures are the most devastating complication of osteoporosis, vertebral compression fractures are by far the most common. Unfortunately, 60 percent to70 percent of spinal fractures are initially asymptomatic, escaping clinical detection yet placing the patients at higher risk for another vertebral facture and subsequent hip fractures."

Researchers found a higher incidence of fractures than in previous studies because many of the spinal fractures were asymptomatic and undiagnosed, he said.

In the past, treatments for osteoporosis, such as bisphosphonate drugs, have been reported to lead to atrial fibrillation; however, the Canadian researchers found no association.

The researchers hypothesize that hyperaldosteronism (high levels of the hormone aldosterone) may provide a plausible explanation for the relationship between chronic heart failure, osteoporosis and atrial fibrillation. Aldosterone, a hormone made in the adrenal gland, helps regulate blood pressure, the balance of fluids and electrolytes.

High levels of aldosterone in past studies have been shown to play a role in osteoporosis related fractures and also have led to atrial fibrillation, Ezekowitz said. "Further study is needed, but it could be that treatment with an aldosterone antagonist like spironolactone could lower the incidence of fractures and atrial fibrillation in these patients."

Further studies also are needed to either confirm or refute a link with hyperaldosteronism, Ezekowitz said.

Limitations of the study include that chest X-rays weren't performed specifically to diagnose spinal fractures and bone mineral density tests were not performed. The study's strengths were the completeness of the description of the patients and that all the chest X-rays were performed at one center where the radiologists were board certified, and the chest X-rays have been evaluated and found to be very specific for spinal fractures.

The researchers are studying whether atrial fibrillation should be considered as a risk factor for fractures in heart failure patients.

Sumit R. Majumdar, M.D., M.P.H., was also a co-author of the study. Author disclosures are on the manuscript.

Anonymous donations to the Heart Function Clinic via University Hospital Foundation in Edmonton, Canada funded the study.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Heart failure patients' osteoporosis often undiagnosed, untreated." ScienceDaily. ScienceDaily, 15 May 2011. <www.sciencedaily.com/releases/2011/05/110510161755.htm>.
American Heart Association. (2011, May 15). Heart failure patients' osteoporosis often undiagnosed, untreated. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/05/110510161755.htm
American Heart Association. "Heart failure patients' osteoporosis often undiagnosed, untreated." ScienceDaily. www.sciencedaily.com/releases/2011/05/110510161755.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins