Featured Research

from universities, journals, and other organizations

Carbon black nanoparticles can cause cell death, inflammation in lungs, researchers find

Date:
May 19, 2011
Source:
University of Iowa Health Care
Summary:
Inhaled carbon black nanoparticles create a double source of inflammation in the lungs, according to new research.

Researchers from the University of Iowa Roy J. and Lucille A. Carver College of Medicine have found that inhaled carbon black nanoparticles create a double source of inflammation in the lungs.

Related Articles


Their findings were published online in the April 27 edition of the Journal of Biological Chemistry. Martha Monick, Ph.D., UI professor of internal medicine, was lead author of the paper which outlined the results.

Monick said researchers expected to find one level of inflammation when cells were exposed to carbon black nanoparticles. They were surprised, however, to find that nanoparticles activated a special inflammatory process and killed cells in a way that further increased inflammation. She said the research showed that the intake of carbon black nanoparticles from sources such as diesel fuel or printer ink caused an initial inflammatory response in lung cells. The surprising results came when the team discovered that these nanoparticles killed macrophages -- immune cells in the lungs responsible for cleaning up and attacking infections -- in a way that also increases inflammation.

"Apoptosis is one way cells die in which all the contents stay in the cell, the cell just keeps shrinking onto itself and the surrounding tissue is protected," Monick said. "We thought that was what was happening with the carbon nanoparticles; we were wrong. A different process called pyroptosis was occurring, causing the cells to burst and spill their contents."

That, she said, can cause a secondary inflammatory response.

Monick cautioned that the doses of carbon black nanoparticles used in the study were much more concentrated than the amounts to which a person might typically be exposed.

"This doesn't mean that walking through a cloud of diesel exhaust will hurt your lungs," she said. "It does show that we may have an environmental exposure that could contribute to inflammation in the lung."

The study was a collaborative project involving researchers in the Department of Internal Medicine in the UI Carver College of Medicine and the Department of Chemistry in the College of Liberal Arts and Sciences. In addition to Monick, a key contributor to the research was Vicki Grassian, Ph.D., UI professor of chemistry who holds the F. Wendell Miller Professorship.

The research team also included Anna C. Reisetter, Linda Powers, and Amit Gupta from internal medicine and Larissa V. Stebounova, and Jonas Baltrusaitis in chemistry.

The study was funded in part by a grant from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Iowa Health Care. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. C. Reisetter, L. V. Stebounova, J. Baltrusaitis, L. Powers, A. Gupta, V. H. Grassian, M. M. Monick. Induction of inflammasome dependent pyroptosis by carbon black nanoparticles. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M111.238519

Cite This Page:

University of Iowa Health Care. "Carbon black nanoparticles can cause cell death, inflammation in lungs, researchers find." ScienceDaily. ScienceDaily, 19 May 2011. <www.sciencedaily.com/releases/2011/05/110518161713.htm>.
University of Iowa Health Care. (2011, May 19). Carbon black nanoparticles can cause cell death, inflammation in lungs, researchers find. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/05/110518161713.htm
University of Iowa Health Care. "Carbon black nanoparticles can cause cell death, inflammation in lungs, researchers find." ScienceDaily. www.sciencedaily.com/releases/2011/05/110518161713.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins