Featured Research

from universities, journals, and other organizations

Early cellular cause of dry eye disease 'seen' for the first time

Date:
June 1, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If you are one of the millions who struggle with dry eye disease, good news is here. New research offers hope for new drugs that treat the cellular cause, rather than its symptoms. This novel research identifies natural killer cells, a type of cell that provides innate immunity to the eyes, as promoting inflammation that is a critical role in the development of the disease.

If you are one of the millions of people around the world who struggle with dry eye disease, good news is on the way. A new research discovery published in the Journal of Leukocyte Biology offers hope for new drugs that treat the cellular cause of the disease rather than its symptoms. That's because the research is the first to identify natural killer (NK) cells, a type of cell that provides innate immunity to the eyes, as promoting the inflammation that plays a critical role in the development of dry eye disease.

"Dry eye disease is suffered by millions of people in the U.S but still lacks effective management," said Yihe Chen, M.D., a researcher involved in the work from the Schepens Eye Research Institute at the Massachusetts Eye and Ear Infirmary of the Department of Ophthalmology at Harvard Medical School in Boston, MA. "Our study has promoted the further understanding of the pathogenesis of dry eye disease, which is fundamental to develop new treatments and thus improve quality of life for those with this disease."

To make their discovery, the scientists tested two groups of mice. The first group was normal and the second group was depleted of NK cells. When both sets of mice were induced with dry eye disease under the same conditions, the disease was less severe in the mice depleted of NK cells than the normal mice. This suggests that NK cells play a pivotal role in the development and severity of the disease, making them a target for the development of new drugs.

According to the National Eye Institute within the U.S. National Institutes of Health, dry eye disease occurs when the eyes do not produce tears properly or when tears evaporate too quickly. As many as five million Americans 50 years of age and older are estimated to have dry eye disease, with the majority affected being women. Tens of millions more are believed to have similar, but less severe symptoms.

"Dry eye disease can be a very serious problem for some people," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "and while drops may help some, they only treat the symptoms of the disease. This research gets us closer to being able to correct the problems before they even occur in the first place."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Chen, S. K. Chauhan, D. R. Saban, Z. Sadrai, A. Okanobo, R. Dana. Interferon-γ-secreting NK cells promote induction of dry eye disease. Journal of Leukocyte Biology, 2011; DOI: 10.1189/jlb.1110611

Cite This Page:

Federation of American Societies for Experimental Biology. "Early cellular cause of dry eye disease 'seen' for the first time." ScienceDaily. ScienceDaily, 1 June 2011. <www.sciencedaily.com/releases/2011/05/110531115406.htm>.
Federation of American Societies for Experimental Biology. (2011, June 1). Early cellular cause of dry eye disease 'seen' for the first time. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2011/05/110531115406.htm
Federation of American Societies for Experimental Biology. "Early cellular cause of dry eye disease 'seen' for the first time." ScienceDaily. www.sciencedaily.com/releases/2011/05/110531115406.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins