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Do-it-yourself brain repair following stroke

Date:
July 11, 2011
Source:
Journal of Clinical Investigation
Summary:
Stroke is a leading cause of long-term disability and death in the United States. New research has now identified a way to exploit one of the brain's self-repair mechanisms to protect nerve cells and enhance brain repair in rodent models of stroke. The authors of the research suggest that this approach could provide a nontoxic treatment for stroke.

Stroke is a leading cause of long-term disability and death in the United States. A team of researchers -- led by Gregory Bix, at Texas A&M College of Medicine, College Station -- has identified a way to exploit one of the brain's self-repair mechanisms to protect nerve cells and enhance brain repair in rodent models of stroke. The authors suggest that this approach could provide a nontoxic treatment for stroke.

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The most common form of stroke (ischemic stroke) occurs when a blood vessel that brings oxygen and nutrients to the brain becomes clogged, for example with a blood clot, causing nerve cells in the affected area to die rapidly. In their study, Bix and colleagues detected in rodent models of stroke elevated levels of domain V, a naturally occurring fragment of the molecule perlecan, suggesting it might have a natural role in repairing the brain after a stroke.

When administered in these models 24 hours after stroke, perlecan domain V protected nerve cells from death and promoted blood vessel growth, a key component of brain repair. The authors therefore suggest that perlecan domain V could provide a therapy that improves stroke outcome by protecting nerve cells and enhancing brain repair.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Boyeon Lee, Douglas Clarke, Abraham Al Ahmad, Michael Kahle, Christi Parham, Lisa Auckland, Courtney Shaw, Mehmet Fidanboylu, Anthony Wayne Orr, Omolara Ogunshola, Andrzej Fertala, Sarah A. Thomas, Gregory J. Bix. Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI46358

Cite This Page:

Journal of Clinical Investigation. "Do-it-yourself brain repair following stroke." ScienceDaily. ScienceDaily, 11 July 2011. <www.sciencedaily.com/releases/2011/07/110711131318.htm>.
Journal of Clinical Investigation. (2011, July 11). Do-it-yourself brain repair following stroke. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/07/110711131318.htm
Journal of Clinical Investigation. "Do-it-yourself brain repair following stroke." ScienceDaily. www.sciencedaily.com/releases/2011/07/110711131318.htm (accessed December 18, 2014).

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