Featured Research

from universities, journals, and other organizations

Greater seizure frequency seen in women with epilepsy during anovulatory cycle

Date:
July 14, 2011
Source:
Wiley-Blackwell
Summary:
A recent multi-center study determined that women with generalized tonic-clonic seizures (GTCS) had a greater number of seizures during anovulatory cycles -- menstrual cycles where an egg is not released -- than in cycles where ovulation occurs. According to the study, reproductive steroids may play a role in GTCS occurrence.

A recent multi-center study determined that women with generalized tonic-clonic seizures (GTCS) had a greater number of seizures during anovulatory cycles -- menstrual cycles where an egg is not released -- than in cycles where ovulation occurs. According to the study published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), reproductive steroids may play a role in GTCS occurrence.

Related Articles


Medical evidence has shown that sex hormones, estradiol and progesterone, have neuroactive properties that can affect seizures. Previous studies by Andrew Herzog, MD, MSc, of Beth Israel Deaconess Medical Center in Boston, Massachusetts and colleagues found that ratios of hormone levels in the blood differ in relation to the ovulatory status of menstrual cycles, with anovulatory cycles having higher estradiol-progesterone ratios during the second half of the menstrual cycle (luteal phase) compared to ovulatory cycles. Further studies have determined that anovulatory cycles are more common among women with epilepsy than in the general population.

To expand on their prior research, Dr. Herzog and colleagues used data collected during the Progesterone Trial Study -- a 3-month investigation of progesterone therapy for focal onset seizures that are difficult to control. Of the 281 women who participated, 92 had both anovulatory and ovulatory cycles during the study period, with progesterone levels of 5 ng/ml measured in the latter part of the menstrual cycle, designating ovulation.

Among the 281 study participants, 37% had GTCS, 81% had complex partial seizures (CPS) and 38% had simple partial seizures (SPS). In the 92 women who had both ovulatory and anovulatory cycles, the seizure percentages were slightly lower, but not significantly different. Researchers determined that the average daily seizure frequency was 30% greater in the women during their anovulatory cycles than in those cycles were ovulation occurred. Seizure frequency did not differ significantly for CPS, SPS, or for all seizures combined.

"Our results showed that GTCS frequency during anovulatory cycles correlate with proportional increases in estradiol-progesterone level ratios, suggesting sex hormones contribute to seizure incidence," concluded Dr. Herzog. "Efficacy results from the phase 3 clinical trial of a progesterone supplement that generated the data for the current study are forthcoming, and may provide a much needed treatment option to control seizures in women with epilepsy."

According to the National Institute of Neurological Disorders and Stroke (NINDS), tonic-clonic seizures, formerly known as grand mal seizures, are the most common type of generalized seizure and cause symptoms that include stiffening of the body, repeated jerking of the arms or legs, and loss of consciousness. The Epilepsy Foundation estimates that 200,000 new cases of epilepsy are diagnosed each year in the U.S., and roughly half of those are generalized onset seizures.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew G. Herzog, Kristen M. Fowler, Michael R. Sperling, Joyce D. Liporace, Laura A. Kalayjian, Christianne N. Heck, Gregory L. Krauss, Barbara A. Dworetzky, Page B. Pennell, and the Progesterone Trial Study Group. Variation of Seizure Frequency with Ovulatory Status of Menstrual Cycles. Epilepsia, 2011; DOI: 10.1111/j.1528-1167.2011.03194.x

Cite This Page:

Wiley-Blackwell. "Greater seizure frequency seen in women with epilepsy during anovulatory cycle." ScienceDaily. ScienceDaily, 14 July 2011. <www.sciencedaily.com/releases/2011/07/110714072944.htm>.
Wiley-Blackwell. (2011, July 14). Greater seizure frequency seen in women with epilepsy during anovulatory cycle. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/07/110714072944.htm
Wiley-Blackwell. "Greater seizure frequency seen in women with epilepsy during anovulatory cycle." ScienceDaily. www.sciencedaily.com/releases/2011/07/110714072944.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins