Featured Research

from universities, journals, and other organizations

Greater seizure frequency seen in women with epilepsy during anovulatory cycle

Date:
July 14, 2011
Source:
Wiley-Blackwell
Summary:
A recent multi-center study determined that women with generalized tonic-clonic seizures (GTCS) had a greater number of seizures during anovulatory cycles -- menstrual cycles where an egg is not released -- than in cycles where ovulation occurs. According to the study, reproductive steroids may play a role in GTCS occurrence.

A recent multi-center study determined that women with generalized tonic-clonic seizures (GTCS) had a greater number of seizures during anovulatory cycles -- menstrual cycles where an egg is not released -- than in cycles where ovulation occurs. According to the study published in Epilepsia, a journal of the International League Against Epilepsy (ILAE), reproductive steroids may play a role in GTCS occurrence.

Medical evidence has shown that sex hormones, estradiol and progesterone, have neuroactive properties that can affect seizures. Previous studies by Andrew Herzog, MD, MSc, of Beth Israel Deaconess Medical Center in Boston, Massachusetts and colleagues found that ratios of hormone levels in the blood differ in relation to the ovulatory status of menstrual cycles, with anovulatory cycles having higher estradiol-progesterone ratios during the second half of the menstrual cycle (luteal phase) compared to ovulatory cycles. Further studies have determined that anovulatory cycles are more common among women with epilepsy than in the general population.

To expand on their prior research, Dr. Herzog and colleagues used data collected during the Progesterone Trial Study -- a 3-month investigation of progesterone therapy for focal onset seizures that are difficult to control. Of the 281 women who participated, 92 had both anovulatory and ovulatory cycles during the study period, with progesterone levels of 5 ng/ml measured in the latter part of the menstrual cycle, designating ovulation.

Among the 281 study participants, 37% had GTCS, 81% had complex partial seizures (CPS) and 38% had simple partial seizures (SPS). In the 92 women who had both ovulatory and anovulatory cycles, the seizure percentages were slightly lower, but not significantly different. Researchers determined that the average daily seizure frequency was 30% greater in the women during their anovulatory cycles than in those cycles were ovulation occurred. Seizure frequency did not differ significantly for CPS, SPS, or for all seizures combined.

"Our results showed that GTCS frequency during anovulatory cycles correlate with proportional increases in estradiol-progesterone level ratios, suggesting sex hormones contribute to seizure incidence," concluded Dr. Herzog. "Efficacy results from the phase 3 clinical trial of a progesterone supplement that generated the data for the current study are forthcoming, and may provide a much needed treatment option to control seizures in women with epilepsy."

According to the National Institute of Neurological Disorders and Stroke (NINDS), tonic-clonic seizures, formerly known as grand mal seizures, are the most common type of generalized seizure and cause symptoms that include stiffening of the body, repeated jerking of the arms or legs, and loss of consciousness. The Epilepsy Foundation estimates that 200,000 new cases of epilepsy are diagnosed each year in the U.S., and roughly half of those are generalized onset seizures.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew G. Herzog, Kristen M. Fowler, Michael R. Sperling, Joyce D. Liporace, Laura A. Kalayjian, Christianne N. Heck, Gregory L. Krauss, Barbara A. Dworetzky, Page B. Pennell, and the Progesterone Trial Study Group. Variation of Seizure Frequency with Ovulatory Status of Menstrual Cycles. Epilepsia, 2011; DOI: 10.1111/j.1528-1167.2011.03194.x

Cite This Page:

Wiley-Blackwell. "Greater seizure frequency seen in women with epilepsy during anovulatory cycle." ScienceDaily. ScienceDaily, 14 July 2011. <www.sciencedaily.com/releases/2011/07/110714072944.htm>.
Wiley-Blackwell. (2011, July 14). Greater seizure frequency seen in women with epilepsy during anovulatory cycle. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/07/110714072944.htm
Wiley-Blackwell. "Greater seizure frequency seen in women with epilepsy during anovulatory cycle." ScienceDaily. www.sciencedaily.com/releases/2011/07/110714072944.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins