Featured Research

from universities, journals, and other organizations

Use of certain biologic therapies for psoriasis do not appear to increase risk for cardiovascular problems

Date:
August 23, 2011
Source:
JAMA and Archives Journals
Summary:
Although some preliminary reports have indicated an increased risk of major adverse cardiovascular events with the use of certain biologic therapies to treat chronic plaque psoriasis, an analysis of previous studies finds no significant difference in the rate of these events among patients who received these medications compared to patients who received placebo, according to a new article.

Although some preliminary reports have indicated an increased risk of major adverse cardiovascular events with the use of certain biologic therapies to treat chronic plaque psoriasis, an analysis of previous studies finds no significant difference in the rate of these events among patients who received these medications compared to patients who received placebo, according to an article in the August 24/31 issue of JAMA.

In the past decade, important new findings have emerged linking autoimmune diseases, including psoriasis, with chronic systemic inflammation and a subsequent increase in cardiovascular risk. It has been proposed that control of inflammation could help reduce cardiovascular illness, according to background information in the article. There have been preliminary reports of an excess number of major adverse cardiovascular events (MACEs [a composite end point of heart attack, cerebrovascular accident, or cardiovascular death]) in randomized controlled trials (RCTs) of psoriasis patients treated with anti-IL-12/23 agents, and a small amount of events reported from studies of anti-tumor necrosis factor alpha (TNF-α) agents for the treatment of psoriasis.

Caitriona Ryan, M.B., B.A.O., B.Ch., of the Baylor Research Institute, Dallas, and colleagues conducted a meta-analysis to evaluate a possible association between biologic therapies for chronic plaque psoriasis (CPP; the most common form of psoriasis, characterized by well-defined patches of red raised skin) and MACEs. The researchers identified for inclusion in the analysis 22 randomized controlled trials of monotherapy studies (with safety outcome data for MACE) of anti-IL-12/23 agents (ustekinumab and briakinumab) and anti-TNF-α agents (adalimumab, etanercept and infliximab) in adults. The total number of participants in these studies was 10,183 patients. The primary outcome that was measured was a MACE during the placebo-controlled phase of treatment in patients receiving at least 1 dose of study agent or placebo.

During the placebo-controlled phases of the anti-IL-12/23 studies, 10 of the 3,179 patients treated with these therapies had a MACE compared with no events in the 1,474 patients treated with placebo. In studies of anti-TNF-α agents, 1 of the 3,858 patients receiving these agents had a MACE compared with 1 of the 1,812 treated with placebo.

"This meta-analysis did not show a significant increase in the risk of MACEs associated with the use of anti-lL-12/23 agents. Limitations of this study, however, prevent us from determining whether these drugs expose psoriasis patients to increased cardiovascular risk. Access to patient-level data for these studies was not granted by any of the study sponsors, which precluded the use of a more statistically robust time-to-event analysis. The small number of MACEs that occurred in placebo-controlled phases of these studies and the limited duration of the placebo-controlled phases reduce the power of this meta-analysis to detect a change in risk," the authors write.

The researchers add that this analysis highlights the inherent limitations of placebo-controlled, clinical trials to reliably interpret the significance of rare events given their current design. "Although RCTs are currently the criterion standard for measuring clinical efficacy in psoriasis therapies, these studies are designed to detect differences in the severity of psoriasis in response to therapy over short periods of treatment and are often underpowered and of too short duration to detect rare or long-term adverse events. Careful consideration of these issues is warranted to best serve patients in these studies and those who are treated once drugs are approved."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Ryan, C. L. Leonardi, J. G. Krueger, A. B. Kimball, B. E. Strober, K. B. Gordon, R. G. Langley, J. A. de Lemos, Y. Daoud, D. Blankenship, S. Kazi, D. H. Kaplan, V. E. Friedewald, A. Menter. Association Between Biologic Therapies for Chronic Plaque Psoriasis and Cardiovascular Events: A Meta-analysis of Randomized Controlled Trials. JAMA: The Journal of the American Medical Association, 2011; 306 (8): 864 DOI: 10.1001/jama.2011.1211

Cite This Page:

JAMA and Archives Journals. "Use of certain biologic therapies for psoriasis do not appear to increase risk for cardiovascular problems." ScienceDaily. ScienceDaily, 23 August 2011. <www.sciencedaily.com/releases/2011/08/110823165344.htm>.
JAMA and Archives Journals. (2011, August 23). Use of certain biologic therapies for psoriasis do not appear to increase risk for cardiovascular problems. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/08/110823165344.htm
JAMA and Archives Journals. "Use of certain biologic therapies for psoriasis do not appear to increase risk for cardiovascular problems." ScienceDaily. www.sciencedaily.com/releases/2011/08/110823165344.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins