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Search for predictors of risk for PTSD: Meaningful associations dependent on reliable measures of pre-existing trauma

Date:
September 6, 2011
Source:
Emory University
Summary:
A new study suggests that certain variants of a gene that helps regulate serotonin (a brain chemical related to mood) may serve as a useful predictor of risk for symptoms related to posttraumatic stress disorder (PTSD) following a trauma.

A new study published in the Archives of General Psychiatry suggests that certain variants of a gene that helps regulate serotonin (a brain chemical related to mood) may serve as a useful predictor of risk for symptoms related to posttraumatic stress disorder (PTSD) following a trauma.

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"One of the critical questions surrounding PTSD is why some individuals are at risk for developing the disorder following a trauma, while others appear to be relatively resilient," says lead author, Kerry J. Ressler, MD, PhD, Howard Hughes Medical Institute investigator and professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine.

"It is known that genetic heritability is one component of the differential risk for PTSD, but the mechanisms remain relatively unknown."

In this study, the researchers were able to look at college students who had been interviewed for a study prior to a 2008 mass shooting on the Northern Illinois University campus, and then were interviewed afterward. The researchers used these prospective psychological data to examine the association between variants in the serotonin transporter gene promoter region of the brain, and PTSD/acute stress disorder symptoms that developed in the aftermath of exposure to the shooting.

"We believe that the strength of this study is the availability of the same validated survey measure to assess PTSD symptoms prior to and after a shared acute traumatic event," explains Ressler, who is also a researcher at the Yerkes National Primate Research Center at Emory.

The data suggest that differential function of the serotonin transporter may mediate differential response to a severe trauma. This is interesting because the gene product is the target for the first-line treatment for PTSD, the selective serotonin reuptake inhibitors (SSRIs). Additionally, variants in the gene have previously been shown to be associated with different risk for depression following life stress.

The researchers concluded that when examined in a relatively homogenous sample with shared trauma and known prior levels of child and adult trauma, this serotonin transporter genotype may serve as a useful predictor of risk for PTSD related symptoms in the weeks and months following trauma.

Importantly, notes Ressler, this is one of likely a number of genes that will ultimately be found to contribute to risk and resilience. As more of these gene pathways are understood, it is hoped that such findings will contribute to improved treatment and prevention as well as better prediction of risk for PTSD following traumatic exposure.

Other researchers involved in the study include Kristina B. Mercer, Howard Hughes Medical Institute and Emory University School of Medicine and Jeffrey F. Quinn, Caitlin A. Fitzgerald, Karen N. Conneely, Charles F. Gillespie, Emory University School of Medicine. Richard T. Barfield and Holly K. Orcutt are from Emory Rollins School of Public Health and Northern Illinois University respectively.

The research was funded by grants from the Joyce Foundation, the Burroughs Wellcome Fund, the National Institute of Child Health and Human Development and the National Institute of Mental Health.

The Robert W. Woodruff Health Sciences Center of Emory University is a non-for-profit academic institution that focuses on teaching,


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristina B. Mercer; Holly K. Orcutt; Jeffrey F. Quinn; Caitlin A. Fitzgerald; Karen N. Conneely; Richard T. Barfield; Charles F. Gillespie; Kerry J. Ressler. Acute and Posttraumatic Stress Symptoms in a Prospective Gene x Environment Study of a University Campus Shooting. Archives of General Psychiatry, 2011; DOI: 10.1001/archgenpsychiatry.2011.109

Cite This Page:

Emory University. "Search for predictors of risk for PTSD: Meaningful associations dependent on reliable measures of pre-existing trauma." ScienceDaily. ScienceDaily, 6 September 2011. <www.sciencedaily.com/releases/2011/09/110905160910.htm>.
Emory University. (2011, September 6). Search for predictors of risk for PTSD: Meaningful associations dependent on reliable measures of pre-existing trauma. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2011/09/110905160910.htm
Emory University. "Search for predictors of risk for PTSD: Meaningful associations dependent on reliable measures of pre-existing trauma." ScienceDaily. www.sciencedaily.com/releases/2011/09/110905160910.htm (accessed February 26, 2015).

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