Featured Research

from universities, journals, and other organizations

Study evaluates intranasal insulin therapy for adults with mild cognitive impairment or Alzheimer’s

Date:
September 13, 2011
Source:
JAMA and Archives Journals
Summary:
Intranasal insulin therapy appears to provide some benefit for cognitive function in patients with amnestic mild cognitive impairment and Alzheimer disease, according to a new study.

Intranasal insulin therapy appears to provide some benefit for cognitive function in patients with amnestic mild cognitive impairment and Alzheimer disease, according to a report published Online First by Archives of Neurology, one of the JAMA/Archives journals.

According to background information in the article, insulin plays a role in a number of functions of the central nervous system. "The importance of insulin in normal brain function is underscored by evidence that insulin dysregulation contributes to the pathophysiology of Alzheimer disease (AD), a disorder characterized in its earliest stages by synaptic loss and memory impairment," the authors write. "Insulin levels and insulin activity in the central nervous system are reduced in AD."

Suzanne Craft, Ph.D., of the Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, and colleagues conducted a randomized controlled trial to evaluate the effects of intranasal insulin therapy on cognition, function, cerebral glucose metabolism and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment (aMCI) or AD.

Study participants were randomized into one of three treatment groups, with 36 participants receiving 20 IU (international unit) of insulin daily, 38 receiving 40 IU of insulin daily, and 30 participants receiving placebo daily for four months. All treatments were administered using a nasal drug delivery device. The authors evaluated the effects of treatment on delayed story recall (how well participants could recall a story told to them immediately after, and after a short time lapse) and the Dementia Severity Rating Scale (DSRS) scores of participants.

Compared with participants in the placebo-controlled group, those receiving 20 IU of insulin daily showed improved delayed story recall, however no improvement was observed for participants receiving 40 IU of insulin. Also, compared with the placebo group, DSRS scores were preserved for both insulin treatment groups. Both insulin doses also appeared to preserve general cognition for younger participants as assessed by the Alzheimer Disease's Assessment Scale-cognitive subscale (ADAS-cog) score as well as functional abilities in adults with AD as assessed by scores on the Alzheimer's Disease Cooperative Study-activities of daily living (ADCS-ADL) scale. Conversely, participants with aMCI showed no change regardless of treatment assignment and participants in the placebo-controlled group showed a slight decline overall in function.

"In conclusion, the results of our pilot trial demonstrate that the administration of intranasal insulin stabilized or improved cognition, function and cerebral glucose metabolism for adults with aMCI or AD," the authors write. "Taken together, these results provide an impetus for future clinical trials of intranasal insulin therapy and for further mechanistic studies of insulin's role in the pathogenesis of AD."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Suzanne Craft; Laura D. Baker; Thomas J. Montine; Satoshi Minoshima; G. Stennis Watson; Amy Claxton; Matthew Arbuckle; Maureen Callaghan; Elaine Tsai; Stephen R. Plymate; Pattie S. Green; James Leverenz; Donna Cross; Brooke Gerton. Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial. Archives of Neurology, 2011; DOI: 10.1001/archneurol.2011.233

Cite This Page:

JAMA and Archives Journals. "Study evaluates intranasal insulin therapy for adults with mild cognitive impairment or Alzheimer’s." ScienceDaily. ScienceDaily, 13 September 2011. <www.sciencedaily.com/releases/2011/09/110912164014.htm>.
JAMA and Archives Journals. (2011, September 13). Study evaluates intranasal insulin therapy for adults with mild cognitive impairment or Alzheimer’s. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/09/110912164014.htm
JAMA and Archives Journals. "Study evaluates intranasal insulin therapy for adults with mild cognitive impairment or Alzheimer’s." ScienceDaily. www.sciencedaily.com/releases/2011/09/110912164014.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins