Featured Research

from universities, journals, and other organizations

First detection of pregnancy protein in older people destined for Alzheimer's disease

Date:
September 29, 2011
Source:
American Chemical Society
Summary:
In an advance toward a much-needed early diagnostic test for Alzheimer's disease (AD), scientists have discovered that older women destined to develop AD have high blood levels of a protein linked to pregnancy years before showing symptoms.

In an advance toward a much-needed early diagnostic test for Alzheimer's disease (AD), scientists have discovered that older women destined to develop AD have high blood levels of a protein linked to pregnancy years before showing symptoms.

Their report appears in ACS' Journal of Proteome Research.

Theo Luider and colleagues explain that more than 26 million people worldwide already have AD, and the numbers are rising with the graying of the population. Doctors can prescribe any of several drugs to slow the disease's advance. But it is important to start treatment as early as possible. Unfortunately, however, no test exists to diagnose patients before obvious memory loss and other symptoms appear. Luider's team decided to look for proteins in the blood that might be used in such a test.

They looked for those proteins in blood samples of 86 people aged 60-90 who participated in a larger study of aged-related brain changes conducted in The Netherlands. Surprisingly, Luider's group found that significant elevations in pregnancy zone protein (PZP) occurred in women an average of 4 years before diagnosis of AD. Scientists long have known that PZP levels rise during pregnancy, but this was the first link with AD. Luider further discovered the apparent source of the PZP in the brain of these women, who were not pregnant: PZP was being produced in senile plaques, degenerated areas of the brain associated with AD.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Linda IJsselstijn, Lennard J. M. Dekker, Christoph Stingl, Marcel M. van der Weiden, Albert Hofman, Johan M. Kros, Peter J. Koudstaal, Peter A. E. Sillevis Smitt, M. Arfan Ikram, Monique M. B. Breteler, Theo M. Luider. Serum Levels of Pregnancy Zone Protein are Elevated in Presymptomatic Alzheimer’s Disease. Journal of Proteome Research, 2011; 110928094303002 DOI: 10.1021/pr200270z

Cite This Page:

American Chemical Society. "First detection of pregnancy protein in older people destined for Alzheimer's disease." ScienceDaily. ScienceDaily, 29 September 2011. <www.sciencedaily.com/releases/2011/09/110928105901.htm>.
American Chemical Society. (2011, September 29). First detection of pregnancy protein in older people destined for Alzheimer's disease. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/09/110928105901.htm
American Chemical Society. "First detection of pregnancy protein in older people destined for Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/09/110928105901.htm (accessed July 29, 2014).

Share This




More Mind & Brain News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins