Featured Research

from universities, journals, and other organizations

New stem cell activity identified in human brain

Date:
September 28, 2011
Source:
St. Joseph's Hospital and Medical Center
Summary:
Researchers have identified a new pathway of stem cell activity in the brain that represents potential targets of brain injuries affecting newborns. The recent study raises new questions of how the brain evolves.

Researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center have identified a new pathway of stem cell activity in the brain that represents potential targets of brain injuries affecting newborns. The recent study, which raises new questions of how the brain evolves, is published in the current issue of Nature.

Related Articles


Nader Sanai, MD, director of Barrow's Brain Tumor Research Center, led this study, which is the first developmental study of human neural stem cells in a region of the brain called the subventricular zone, the tissue structure in which brain stem cells reside. Also participating in the study were researchers from University of California San Francisco and the University of Valencia in Spain.

The findings revealed that there is a pathway of young migrating neurons targeting the prefrontal cortex of the human brain in the first few months of life. After the first year of life, the subventricular zone of the brain slows down, tapering production of new brain cells by the time a child is 18-months and then to nearly zero by age two. This revelation settles conflicting prior reports that suggested that human neural stem cell cells remain highly active into adulthood.

"In the first few months of life, we identified streams of newly-generated cells from the subventricular portion of the brain moving toward the frontal cortex," says Dr. Sanai. "The existence of this new pathway, which has no known counterpart in all other studied vertebrates, raises questions about the mechanics of how the human brain develops and has evolved."

Researchers believe this study holds important implications for the understanding of neonatal brain diseases that can cause death or devastating, life-long brain damage. These conditions include germinal matrix hemorrhages, the most common type of brain hemorrhage that occurs in infants; and perinatal hypoxic -- ischaemic injuries, exposure to low oxygen and decreased blood flow that can lead to diseases such as cerebral palsy and seizure disorders.

"The first year of human life has a window of vulnerability, as well as tremendous opportunity, for the brain," says Dr. Sanai. "It's a period of incredible growth, organization, and flexibility, as fresh neural connections are created, broken, and remade. A better understanding of how things can go wrong in that critical period could ultimately improve the chances that things will go right."


Story Source:

The above story is based on materials provided by St. Joseph's Hospital and Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nader Sanai, Thuhien Nguyen, Rebecca A. Ihrie, Zaman Mirzadeh, Hui-Hsin Tsai, et al. Corridors of migrating neurons in the human brain and their decline during infancy. Nature, 28 September 2011 DOI: 10.1038/nature10487

Cite This Page:

St. Joseph's Hospital and Medical Center. "New stem cell activity identified in human brain." ScienceDaily. ScienceDaily, 28 September 2011. <www.sciencedaily.com/releases/2011/09/110928142452.htm>.
St. Joseph's Hospital and Medical Center. (2011, September 28). New stem cell activity identified in human brain. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2011/09/110928142452.htm
St. Joseph's Hospital and Medical Center. "New stem cell activity identified in human brain." ScienceDaily. www.sciencedaily.com/releases/2011/09/110928142452.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins