Featured Research

from universities, journals, and other organizations

BPA exposure in utero may increase predisposition to breast cancer

Date:
October 3, 2011
Source:
The Endocrine Society
Summary:
A recent study found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.

A recent study accepted for publication in Molecular Endocrinology, a journal of The Endocrine Society, found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.

BPA, a human-made chemical produced and marketed largely for specific industrial purposes, is detected in body fluids of more than 90 percent of the human population. It was originally synthesized as an estrogenic compound and there has been concern that exposure to BPA could have developmental effects on various hormone-responsive organs including the mammary gland.

"I want it to be clear that we do not provide evidence that BPA exposure causes breast cancer per se," said Cathrin Brisken, MD, of the Swiss Institute for Experimental Cancer Research and co-author of the study. "We do provide evidence that BPA exposure alters mammary gland development and that this may increase the predisposition of the breast to breast cancer."

In this study, researchers mimicked human exposure to BPA as it occurs with beverages and food from BPA containing vessels (such as plastics and the lining of tin cans) by adding the compound to the drinking water of breeding mice. Female pups born from BPA-consuming parents were transferred to a BPA-free environment at weaning and followed over time.

Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk.

Furthermore, researchers found that adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what is seen upon similar exposure to another estrogenic compound, diethyllbestrol (DES). Uterine exposure to DES in the human population has been shown to increase the relative risk of getting breast cancer two-fold as women reach their fifties.

"While we cannot extrapolate these results directly from mice to humans, the possibility that some of the increase in breast cancer incidence observed over the past decades may be attributed to exposure to BPA cannot be dismissed," said Brisken. "Our study suggests that pregnant and breastfeeding mothers should avoid exposure to BPA as it may affect their daughters' breast tissue."

Other researchers working on the study include Ayyakkannu Ayyanan, Ouahiba Laribi, Sonia Schuepbach-Mallepell, Christina Schrick, Maria Gutierrez, Tamara Tanos and Ozden Yalcin-Ozuysal of the Swiss Institute for Experimental Cancer Research; and Gregory Lefebvre and Jacques Rougemont of Ιcole polytechnique fιdιrale de Lausanne in Switzerland.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Ayyanan, O. Laribi, S. Schuepbach-Mallepell, C. Schrick, M. Gutierrez, T. Tanos, G. Lefebvre, J. Rougemont, O. Yalcin-Ozuysal, C. Brisken. Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number. Molecular Endocrinology, 2011; DOI: 10.1210/me.2011-1129

Cite This Page:

The Endocrine Society. "BPA exposure in utero may increase predisposition to breast cancer." ScienceDaily. ScienceDaily, 3 October 2011. <www.sciencedaily.com/releases/2011/10/111003080421.htm>.
The Endocrine Society. (2011, October 3). BPA exposure in utero may increase predisposition to breast cancer. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/10/111003080421.htm
The Endocrine Society. "BPA exposure in utero may increase predisposition to breast cancer." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003080421.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins