Featured Research

from universities, journals, and other organizations

Faulty intellectual disability genes linked to older dads at conception, research finds

Date:
October 4, 2011
Source:
BMJ-British Medical Journal
Summary:
Chromosomal abnormalities linked to intellectual disability can be traced back to the father, particularly those who are older when the child is conceived, new research finds.

Chromosomal abnormalities linked to intellectual disability can be traced back to the father, particularly those who are older when the child is conceived, finds research published online in the Journal of Medical Genetics.

Related Articles


Chromosomal abnormalities are caused by copy number variations, or CNVs. These are structural variations resulting in missing, repeated, inverted or misplaced DNA sequences in cells.

They can be inherited or arise anew, and are a common cause of disease. However, little is known about how CNVs are formed, for example, if they occur more frequently on the DNA sequence passed on by the mother or the father, or if parental age is important.

The research team systematically analysed the prevalence of rare CNVs in almost 3500 people with intellectual disabilities between 2006 and 2010.

They found CNVs which had arisen anew, as opposed to being inherited, in 227 people, meaning the prevalence was around twice as common in this group as among people with autism and three times as common as among those with asthma.

Further analysis to determine the parental origin of the CNVs in the 118 people for whom data were available, showed that 90 had come from the father, and that three quarters represented missing DNA sequences.

The researchers compared the father's age at time of birth in the group with CNVs with people with no intellectual disability, matching for ethnicity and era of birth to minimise the impact of any cultural or social factors. But they found no differences in paternal age between the two groups.

The researchers then divided people with CNVs into two groups -- those with CNVs occurring in regions of the genome with highly repetitive DNA sequences, and those with CNVs occurring in non -- repetitive DNA sequences.

They also compared paternal ages in both groups with those of the people without any intellectual disability.

A significant increase in the father's age was found in the group of CNVs in non- repetitive DNA sequences -- which accounted for most CNVs -- providing a crucial insight into the understanding of how and why disease -- causing CNVs are formed, say the authors.

The findings also indicate that newly arising CNVs not only originate more often from the father's DNA, but that the father's age has a role, the authors add.

"In conclusion, our data provide for the first time convincing evidence that CNVs in intellectual disability are largely paternal in origin," they write.

And they suggest that both the gender and age bias can be explained by ongoing cell divisions of self -- renewing sperm cells during the fetal development of boys -- with the potential for mistakes -- as well as impaired DNA genesis and repair as a consequence of the aging process.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jayne Y. Hehir-Kwa, Benjamín Rodríguez-Santiago, Lisenka E. Vissers, Nicole de Leeuw, Rolph Pfundt, Jan K. Buitelaar, Luis A. Pérez-Jurado, Joris A. Veltman. De novo copy number variants associated with intellectual disability have a paternal origin and age bias. Journal of Medical Genetics, 2011; DOI: 10.1136/jmedgenet-2011-100147

Cite This Page:

BMJ-British Medical Journal. "Faulty intellectual disability genes linked to older dads at conception, research finds." ScienceDaily. ScienceDaily, 4 October 2011. <www.sciencedaily.com/releases/2011/10/111003195249.htm>.
BMJ-British Medical Journal. (2011, October 4). Faulty intellectual disability genes linked to older dads at conception, research finds. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/10/111003195249.htm
BMJ-British Medical Journal. "Faulty intellectual disability genes linked to older dads at conception, research finds." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003195249.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins