Featured Research

from universities, journals, and other organizations

Faulty intellectual disability genes linked to older dads at conception, research finds

Date:
October 4, 2011
Source:
BMJ-British Medical Journal
Summary:
Chromosomal abnormalities linked to intellectual disability can be traced back to the father, particularly those who are older when the child is conceived, new research finds.

Chromosomal abnormalities linked to intellectual disability can be traced back to the father, particularly those who are older when the child is conceived, finds research published online in the Journal of Medical Genetics.

Chromosomal abnormalities are caused by copy number variations, or CNVs. These are structural variations resulting in missing, repeated, inverted or misplaced DNA sequences in cells.

They can be inherited or arise anew, and are a common cause of disease. However, little is known about how CNVs are formed, for example, if they occur more frequently on the DNA sequence passed on by the mother or the father, or if parental age is important.

The research team systematically analysed the prevalence of rare CNVs in almost 3500 people with intellectual disabilities between 2006 and 2010.

They found CNVs which had arisen anew, as opposed to being inherited, in 227 people, meaning the prevalence was around twice as common in this group as among people with autism and three times as common as among those with asthma.

Further analysis to determine the parental origin of the CNVs in the 118 people for whom data were available, showed that 90 had come from the father, and that three quarters represented missing DNA sequences.

The researchers compared the father's age at time of birth in the group with CNVs with people with no intellectual disability, matching for ethnicity and era of birth to minimise the impact of any cultural or social factors. But they found no differences in paternal age between the two groups.

The researchers then divided people with CNVs into two groups -- those with CNVs occurring in regions of the genome with highly repetitive DNA sequences, and those with CNVs occurring in non -- repetitive DNA sequences.

They also compared paternal ages in both groups with those of the people without any intellectual disability.

A significant increase in the father's age was found in the group of CNVs in non- repetitive DNA sequences -- which accounted for most CNVs -- providing a crucial insight into the understanding of how and why disease -- causing CNVs are formed, say the authors.

The findings also indicate that newly arising CNVs not only originate more often from the father's DNA, but that the father's age has a role, the authors add.

"In conclusion, our data provide for the first time convincing evidence that CNVs in intellectual disability are largely paternal in origin," they write.

And they suggest that both the gender and age bias can be explained by ongoing cell divisions of self -- renewing sperm cells during the fetal development of boys -- with the potential for mistakes -- as well as impaired DNA genesis and repair as a consequence of the aging process.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jayne Y. Hehir-Kwa, Benjamín Rodríguez-Santiago, Lisenka E. Vissers, Nicole de Leeuw, Rolph Pfundt, Jan K. Buitelaar, Luis A. Pérez-Jurado, Joris A. Veltman. De novo copy number variants associated with intellectual disability have a paternal origin and age bias. Journal of Medical Genetics, 2011; DOI: 10.1136/jmedgenet-2011-100147

Cite This Page:

BMJ-British Medical Journal. "Faulty intellectual disability genes linked to older dads at conception, research finds." ScienceDaily. ScienceDaily, 4 October 2011. <www.sciencedaily.com/releases/2011/10/111003195249.htm>.
BMJ-British Medical Journal. (2011, October 4). Faulty intellectual disability genes linked to older dads at conception, research finds. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/10/111003195249.htm
BMJ-British Medical Journal. "Faulty intellectual disability genes linked to older dads at conception, research finds." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003195249.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) — A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) — That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) — The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com
Michigan Man Sees Thanks to 'bionic Eye'

Michigan Man Sees Thanks to 'bionic Eye'

AP (Apr. 23, 2014) — A legally blind Michigan man is 'seeing something new every day' thanks to a high-tech retinal implant procedure. He's one of the first in the country to receive a 'bionic eye' since the federal government approved the surgery. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins