Featured Research

from universities, journals, and other organizations

Family history may have more important role than previously thought in development of Alzheimer disease

Date:
October 11, 2011
Source:
JAMA and Archives Journals
Summary:
Family history of Alzheimer disease is associated with several age-related changes that appear to influence Alzheimer disease (AD) biomarker abnormalities beyond the increased risk of the APOE4 gene, according to a new report.

Family history of Alzheimer disease is associated with several age-related changes that appear to influence Alzheimer disease (AD) biomarker abnormalities beyond the increased risk of the APOE4 gene, according to a report published in the October issue of Archives of Neurology, one of the JAMA/Archives journals.

According to background information in the article, the "recent advances suggest that Alzheimer disease (AD) has a lengthy period in which cerebral lesions gradually accumulate in the absence of symptoms, eventually causing sufficient synaptic and neuronal damage to result in symptomatic AD. Since 2005, Antecedent Biomarkers for AD: The Adult Children Study (ACS) has enrolled a cohort of cognitively normal 43 -- to 76-year-old individuals in an extensive study of biomarkers for AD before it symptomatic stages."

Chengjie Xiong, Ph.D., from Washington University School of Medicine, St. Louis, and colleagues assessed whether family history alone is associated with AD risk beyond that of the ε4 allele of apolipoprotein E (APOE4), a genetic biomarker indicating higher risk for susceptibility for AD. A total of 269 cognitively normal middle-to older-age individuals with and without a family history of Alzheimer disease participated in the study. A family history was identified as having at least one biological parent with age at onset for dementia of the Alzheimer type (DAT) of less than 80 years, and a negative family history was defined as both biological parents living to age 70 or longer without DAT. The participants underwent clinical and cognitive measures, including magnetic resonance imaging-based brain volumes, cerebrospinal fluid biomarkers (CSF; collected by lumbar puncture), and positron emission tomography using the [11C] benzothiazole tracer, Pittsburgh compound B [PET PIB].

"Age-adjusted cerebrospinal fluid Aβ42 was decreased for individuals with APOE4 compared with the level for those without, and the decrease was larger for individuals with a positive family history compared with the decrease for those without," the authors report. "For individuals younger than 55, an age-related increase in mean cortical binding potential was associated with APOE4 but not family history. For individuals older than 55, a positive family history and a positive APOE4 implied the fastest age-related increase in mean cortical binding potential." The authors add, "the current results point to the likelihood of non-APOE susceptibility genes for AD..."

." ..among cognitively normal middle- to older-aged individuals, age-related changes in brain Aβ42 metabolism as well as local microstructural characteristics of water diffusion in certain brain regions are influenced by family history of AD, suggesting that they are likely early events in AD pathogenesis," the authors write. "Whereas cognitive changes might be later events in the neurodegenerative sequence before the onset of DAT, changes in CSF and PIB biomarkers have the potential to capture the earliest possible antecedent events," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Xiong, C. M. Roe, V. Buckles, A. Fagan, D. Holtzman, D. Balota, J. Duchek, M. Storandt, M. Mintun, E. Grant, A. Z. Snyder, D. Head, T. L. S. Benzinger, J. Mettenburg, J. Csernansky, J. C. Morris. Role of Family History for Alzheimer Biomarker Abnormalities in the Adult Children Study. Archives of Neurology, 2011; 68 (10): 1313 DOI: 10.1001/archneurol.2011.208

Cite This Page:

JAMA and Archives Journals. "Family history may have more important role than previously thought in development of Alzheimer disease." ScienceDaily. ScienceDaily, 11 October 2011. <www.sciencedaily.com/releases/2011/10/111010214527.htm>.
JAMA and Archives Journals. (2011, October 11). Family history may have more important role than previously thought in development of Alzheimer disease. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2011/10/111010214527.htm
JAMA and Archives Journals. "Family history may have more important role than previously thought in development of Alzheimer disease." ScienceDaily. www.sciencedaily.com/releases/2011/10/111010214527.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins