Featured Research

from universities, journals, and other organizations

Updated cervical cancer screening evidence

Date:
October 17, 2011
Source:
American College of Physicians
Summary:
In 2003 the U.S. Preventive Services Task Force published recommendations for cervical cancer screening. To inform an updated recommendation, researchers performed two reviews of the published literature focusing on evidence that has become available since the 2003 recommendation.

In 2003 the U.S. Preventive Services Task Force (USPSTF) published recommendations for cervical cancer screening. To inform an updated recommendation, researchers performed two reviews of the published literature focusing on evidence that has become available since the 2003 recommendation.

The first article reviewed published articles comparing liquid-based cytology to the conventional Pap smear. With a conventional Pap smear, the clinician collects cells from a woman's cervix and transfers them to a slide for microscopic evaluation. With a liquid-based test, cervical cells are preserved in fluid, rather than smeared directly onto a slide. The same sample can be used for HPV testing.

The researchers found that conventional and liquid-based pap tests did not differ substantially in measures of relative detection or absolute sensitivity or specificity for detection of precancerous cells. However, the liquid-based test produced fewer unsatisfactory slides than conventional testing. Available evidence, though minimal, suggested no substantial difference in harms between the two tests.

Researchers also reviewed published research to assess the benefit and harms of HPV testing in women 30 years and older as an alternative or adjunct to conventional cytology screening. They found that HPV testing was more sensitive than cytology, but there was reduced specificity. While HPV-enhanced screening strategies offer a potential cancer prevention benefit compared with Pap testing alone, there is insufficient evidence to justify substituting HPV for cytology at the population level.

In terms of HPV-screening harms, false positive screening results and diagnosis of regressive or non-progressive histologic pre-disease could result in harms from unnecessary procedures or overtreatment. In addition, women diagnosed with HPV (especially young women for whom the disease may clear on its own) may experience unnecessary anxiety. At this time, researchers need more evidence in order to understand the population impact of HPV testing as a cervical cancer screening tool.

A second review focused on the appropriate ages at which to begin and end cervical cancer screening. Because cervical cancer is rare among women under the age of 20, the research supports beginning screening at age 21. If a woman aged 65 or older has had adequate recent screening with normal Pap smear result and is not at otherwise high risk for cervical cancer, the research suggests that she can end screening age 65.

The evidence reviews have been used to develop a draft recommendation statement that will be posted to the USPSTF website for public comment on October 19th. The final recommendation will be published in Annals at a later date.


Story Source:

The above story is based on materials provided by American College of Physicians. Note: Materials may be edited for content and length.


Cite This Page:

American College of Physicians. "Updated cervical cancer screening evidence." ScienceDaily. ScienceDaily, 17 October 2011. <www.sciencedaily.com/releases/2011/10/111017171500.htm>.
American College of Physicians. (2011, October 17). Updated cervical cancer screening evidence. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/10/111017171500.htm
American College of Physicians. "Updated cervical cancer screening evidence." ScienceDaily. www.sciencedaily.com/releases/2011/10/111017171500.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins