Featured Research

from universities, journals, and other organizations

Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic

Date:
October 18, 2011
Source:
Columbia University's Mailman School of Public Health
Summary:
A new study uses a mathematical model to predict the potential impact of expanding treatment to discordant couples on controlling the global HIV epidemic -- in these couples one partner has HIV infection. The research is among the first to predict the effect of the expansion of such treatment in couples on the HIV epidemic in certain African countries.

A new study uses a mathematical model to predict the potential impact of expanding treatment to discordant couples on controlling the global HIV epidemic-- in these couples one partner has HIV infection and the other does not. The research conducted at ICAP at Columbia University's Mailman School of Public Health and the Semel Institute of Neuroscience and Human Behavior at University of California in Los Angeles (UCLA) is the first to predict the effect of the expansion of such treatment in couples on the HIV epidemic in certain African countries.

Related Articles


In "Modeling the Impact on the HIV Epidemic of Treating Discordant Couples with Antiretrovirals to Prevent Transmission," authors Wafaa El-Sadr, MD, MPH, MPA, director of ICAP at the Mailman School, and Brian Coburn, PhD and Sally Blower, PhD at UCLA's Center for Biomedical Modeling, designed a mathematical model that was able to determine the number of infections prevented as a result of treating discordant couples. They used their model to make predictions for Ghana, Lesotho, Malawi and Rwanda. Full study findings were e-published on October 11, 2011 in the Journal, AIDS.

The authors use data for their modeling from a recent clinical study, HPTN 052, that showed that treatment of the HIV infected individuals in couples where the other partner was not HIV infected was successful in reducing transmission by 96 percent. "The findings from the modeling study provide insights into what to expect at a country level of expanding such a prevention strategy," noted Dr. El-Sadr, "Getting information to countries with regards to what they can expect from scale up of treatment for discordant couples on their epidemics is critical to their decision making."

"The most important aspect of our study is that by using a model to scale up the results of a clinical trial, we were able to predict the effectiveness of the intervention in controlling HIV epidemics," said Dr. Coburn. "It was very exciting to find that this couples-based intervention could be extremely effective." Dr. Blower added, "Our findings are very important as they show the intervention may be very successful in certain countries but not in others. This means we can use our model to identify which specific countries should begin to rollout this intervention."

The authors also demonstrate a practical approach for identifying countries where the expansion of HIV treatment in discordant couples is likely to have a strong effect in terms of preventing further spread of HIV. Such information is of great value as policy makers and public health leaders tackle tough decision in terms of determining their HIV control programs.


Story Source:

The above story is based on materials provided by Columbia University's Mailman School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. El-Sadr WM, Coburn BJ, Blower SM. Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission. AIDS, 2011 [link]

Cite This Page:

Columbia University's Mailman School of Public Health. "Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic." ScienceDaily. ScienceDaily, 18 October 2011. <www.sciencedaily.com/releases/2011/10/111018121840.htm>.
Columbia University's Mailman School of Public Health. (2011, October 18). Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2011/10/111018121840.htm
Columbia University's Mailman School of Public Health. "Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic." ScienceDaily. www.sciencedaily.com/releases/2011/10/111018121840.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins