Featured Research

from universities, journals, and other organizations

Researchers examine BPA and breast cancer link

Date:
October 20, 2011
Source:
University of Alabama at Birmingham
Summary:
Chronic low-level exposure to a compound found in a variety of plastic household items could pose a threat to women who overproduce a protein linked with breast cancer, say researchers.

Chronic low-level exposure to a compound found in a variety of plastic household items could pose a threat to women who overproduce a protein linked with breast cancer, say researchers at University of Alabama at Birmingham.

Coral Lamartiniere, Ph.D., professor in the Department of Pharmacology and Toxicology and senior scientist in the UAB Comprehensive Cancer Center, and postdoctoral fellow Sarah Jenkins, Ph.D., assessed the effect of chronic, oral exposure to the compound bisphenol A (BPA) in mice genetically modified to overproduce the protein HER2/erbB2, present in about 15-30 percent of women with breast cancer. The results were published online Oct. 12, 2011, by the journal Environmental Health Perspectives.

"We found the lower doses of BPA to be capable of activating several growth-factor-receptor pathways that previously have been implicated in cancer. This was not observed with the higher BPA doses," Jenkins says. "This is counterintuitive since BPA in low levels was presumed to be safe."

BPA is an industrial compound primarily used to manufacture polycarbonate plastic and epoxy resins and it is commonly found in household items including kitchen utensils, food storage containers, travel mugs and metal can linings. Animal studies have linked BPA to a variety of health problems such as infertility, prostate cancer and breast cancer, but not without disagreement as to how and whether such findings can be extrapolated to humans. Most BPA research has been centered on early-life exposure in animals, linking low doses of BPA administered early in life -- prenatal, pre-pubertal or a combination of the two -- to an increased risk of mammary cancer later in life.

"Although this study did not study breast cancer in humans, the results suggest that chronic low-level BPA exposure could pose a particular threat to women with breast cancer who overproduce this protein," Jenkins says.


Story Source:

The above story is based on materials provided by University of Alabama at Birmingham. The original article was written by Beena Thannickal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sarah Jenkins, Jun Wang, Isam Eltoum, Renee Desmond, Coral A. Lamartiniere. Chronic Oral Exposure to Bisphenol A Results in a Non-Monotonic Dose Response in Mammary Carcinogenesis and Metastasis in MMTV-erbB2 Mice. Environmental Health Perspectives, 2011; DOI: 10.1289/ehp.1103850

Cite This Page:

University of Alabama at Birmingham. "Researchers examine BPA and breast cancer link." ScienceDaily. ScienceDaily, 20 October 2011. <www.sciencedaily.com/releases/2011/10/111018214107.htm>.
University of Alabama at Birmingham. (2011, October 20). Researchers examine BPA and breast cancer link. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2011/10/111018214107.htm
University of Alabama at Birmingham. "Researchers examine BPA and breast cancer link." ScienceDaily. www.sciencedaily.com/releases/2011/10/111018214107.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins