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Cerebrospinal fluid test can pick up Alzheimer's before symptoms appear

Date:
December 21, 2011
Source:
University of Gothenburg
Summary:
Analysis of the cerebrospinal fluid can detect whether a person has Alzheimer’s disease before symptoms appear. Researchers have studied biomarkers that offer more reliable diagnosis and, in the longer term, the possibility of effective new treatments.

Analysis of the cerebrospinal fluid can detect whether a person has Alzheimer's disease before symptoms appear. Researchers at the Sahlgrenska Academy have studied biomarkers that offer more reliable diagnosis and, in the longer term, the possibility of effective new treatments.

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In Alzheimer's disease, a protein fragment called beta-amyloid forms clumps between the nerve cells of the brain, causing the disease's characteristic effects on memory and function. The nerve fibres also become tangled, causing certain proteins to be released into the cerebrospinal fluid (CSF).

Led by Kaj Blennow, one of the world's leading Alzheimer's experts, researchers at the University of Gothenburg's Sahlgrenska Academy have developed a way of measuring these proteins and protein fragments in the CSF so that they can be used as biomarkers -- substances that reflect biological processes in the body and allow more reliable diagnoses in people with cognitive disorders.

Detect at early stage

"We found that levels of these proteins change in the CSF even with early symptoms, and we will probably be able to detect changes in the brain at a very early stage of the disease," says doctoral student Niklas Mattsson, whose thesis builds on the results.

To promote wider use of these new biomarkers, the researchers in Gothenburg have established an international quality control programme for these measurements. Besides facilitating diagnosis, the biomarkers could also be used when new drugs for Alzheimer's are tested.

Thesis.


Story Source:

The above story is based on materials provided by University of Gothenburg. The original article was written by Krister Svahn. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "Cerebrospinal fluid test can pick up Alzheimer's before symptoms appear." ScienceDaily. ScienceDaily, 21 December 2011. <www.sciencedaily.com/releases/2011/12/111220133546.htm>.
University of Gothenburg. (2011, December 21). Cerebrospinal fluid test can pick up Alzheimer's before symptoms appear. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2011/12/111220133546.htm
University of Gothenburg. "Cerebrospinal fluid test can pick up Alzheimer's before symptoms appear." ScienceDaily. www.sciencedaily.com/releases/2011/12/111220133546.htm (accessed March 28, 2015).

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