Featured Research

from universities, journals, and other organizations

Potential boost for IVF success

Date:
January 5, 2012
Source:
Cardiff University
Summary:
A new technique has already been successfully used in mice to identify embryos likely to result in a successful pregnancy. A new study suggests the same technique could be used in humans, potentially boosting IVF success rates and helping to reduce the number of multiple births.

A new technique successfully used in mice to identify embryos likely to result in a successful pregnancy could be used in humans, according to University scientists.

The discovery could potentially boost IVF success rates and help to reduce the number of multiple births.

The findings, published in the international journal, Fertility and Sterility and funded by the Wellcome Trust, used an advanced imaging technique to track the discrete movements inside an egg that occur during stimulation at fertilization.

The Cardiff scientists worked with a team in Oxford University to analyse the internal contents of the human egg or cytoplasm to observe distinct rhythmic patterns.

"Current IVF treatment involves fertilising eggs in the laboratory and then choosing those embryos considered to be the healthiest for implantation into the mother's womb, using selection criteria such as the number and appearance of cells produced during the division process," according to Professor Karl Swann, School of Medicine, who led the research.

"However, the implantation of selected eggs using current methods requires days in culture and does not always succeed."

"We already know from previous research in mice that sperm entry into the mouse egg triggers "rhythmic cytoplasmic motions," which may help to predict successful embryo development. Adopting this key method we have now been able to show that the same type of rhythmic movements occur in human eggs," he added.

Eggs that had failed to fertilise following IVF treatment were donated by patients attending the IVF Wales clinic, the fertility unit at Cardiff's University Hospital of Wales. In a HFEA-approved procedure, the eggs were injected with an egg-activating sperm-specific protein ('PLC-zeta') and then imaged over a period of several hours.

The scientists were able to view distinct internal movements or spasms which is the first time that they have been detected in human eggs These movements correlate exquisitely with the exact timing of biochemical changes occurring at fertilisation. The scientists hope that this information could help provide an early and effective indication of viability of a successful pregnancy in human IVF.

Professor Swann added: "Previous analysis of mouse fertilisation have suggested that using this technique may provide an early and effective indication of a successful pregnancy after IVF. We have now discovered that this method has the potential to be applied to human eggs.

"There is a still a great deal of additional research to confirm whether these movements directly correlate with positive pregnancy -- but this technique holds the promise of predicting the best embryo for IVF which should help cut down multiple pregnancies that often occurs during IVF treatment as a result of transferring several embryos at a time."


Story Source:

The above story is based on materials provided by Cardiff University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Karl Swann, Shane Windsor, Karen Campbell, Khalil Elgmati, Michail Nomikos, Magdalena Zernicka-Goetz, Nazar Amso, F. Anthony Lai, Adrian Thomas, Christopher Graham. Phospholipase C-ζ-induced Ca2 oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertility and Sterility, 2012; DOI: 10.1016/j.fertnstert.2011.12.013

Cite This Page:

Cardiff University. "Potential boost for IVF success." ScienceDaily. ScienceDaily, 5 January 2012. <www.sciencedaily.com/releases/2012/01/120103135137.htm>.
Cardiff University. (2012, January 5). Potential boost for IVF success. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2012/01/120103135137.htm
Cardiff University. "Potential boost for IVF success." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103135137.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins