Featured Research

from universities, journals, and other organizations

Quitting smoking: Starting Chantix earlier may make it easier to quit

Date:
January 9, 2012
Source:
University at Buffalo
Summary:
Smokers planning to kick the habit may have more success if they begin using a cessation medication several weeks before they actually try to quit.

Smokers planning to kick the habit may have more success if they begin using a cessation medication several weeks before they actually try to quit. Those are the results of a clinical trial conducted by researchers at the University at Buffalo, Roswell Park Cancer Institute (RPCI) and other institutions published recently in Clinical Pharmacology and Therapeutics.

Related Articles


The study focused on 35 women and 25 men, all smokers from Western New York who were on average 48 years old and smoked a pack of cigarettes per day. Participants who were randomized to take the smoking cessation medication varenicline (marketed as Chantix) for four weeks prior to trying to quit smoking were more likely to successfully quit smoking than those who took varenicline for just one week before quitting, which is the current standard therapy for the drug. Everyone took the medication for an additional 11 weeks after the quit day.

"Varenicline was designed to make smoking less rewarding, and our data suggests that it does that better when people take it for a few extra weeks before quitting," says Larry W. Hawk Jr., PhD, lead author and associate professor of psychology in the UB College of Arts and Sciences "If this finding holds up in larger studies, it could have a major impact on public health."

"We saw nearly full compliance, which suggests that this is not only a well-tolerated therapy, but one people can realistically stick with," says co-author Martin C. Mahoney, MD, PhD, associate professor of oncology in RPCI's Departments of Medicine and Health Behavior and clinical associate professor in UB's School of Public Health and Health Professions and School of Medicine and Biomedical Sciences.

While many participants reported mild nausea, Mahoney says, the researchers found that the symptoms typically dissipated after a couple of weeks and may have helped reduce their desire to smoke.

"Whether through changes in taste or nausea, it seems this extra varenicline reduces smoking rates before people try to quit," Hawk says. "These changes should make it easier to quit smoking, but we also know that it takes some period of time for this new learning to occur. That's why we decided to see if a longer period of treatment with varenicline before smokers tried to quit would result in better outcomes, and it did in this small study."

Of special interest was the fact that women who took varenicline for four weeks were especially likely to reduce their smoking, possibly because they reported more nausea in the pre-quit period. After three weeks of treatments with varenicline, women reduced their smoking by more than 50 percent, on average. The men who took the varenicline for four weeks reduced their smoking by 26 percent. The researchers say that much larger studies are needed to tell whether the gender differences are real.

"This study suggests we may be able to take the most effective smoking-cessation treatment we have and make it work 50 percent better, just by giving the medication for a few weeks before smokers attempt to quit," concludes Hawk.

In addition to Hawk and Mahoney, co-authors are Rebecca L. Ashare, PhD, Nicolas J. Schlienz, Stephen T. Tiffany, PhD, Julie C. Gass, Jessica D. Rhodes, all of UB's Department of Psychology; Shaun Fickling Lohnes of Roswell Park, and K. Michael Cummings, PhD, former chair of the Department of Health Behavior at Roswell Park, now at the Medical University of South Carolina.

The study was funded in part by a 2008 Global Research Award for Nicotine Dependence (GRAND), an independent, investigator-initiated research program sponsored by Pfizer, which manufactures varenicline, and by the National Institute for Drug Abuse.

The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system and its largest and most comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Quitting smoking: Starting Chantix earlier may make it easier to quit." ScienceDaily. ScienceDaily, 9 January 2012. <www.sciencedaily.com/releases/2012/01/120105142451.htm>.
University at Buffalo. (2012, January 9). Quitting smoking: Starting Chantix earlier may make it easier to quit. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2012/01/120105142451.htm
University at Buffalo. "Quitting smoking: Starting Chantix earlier may make it easier to quit." ScienceDaily. www.sciencedaily.com/releases/2012/01/120105142451.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
Obamacare's New Supreme Court Battle

Obamacare's New Supreme Court Battle

Washington Post (Mar. 4, 2015) The Affordable Care Act is facing another challenge at the Supreme Court in King v. Burwell, which deals with subsidies for health insurance. The case could cut out a major provision of Obamacare, causing the law to unravel. Here’s what you need to know about the case. Video provided by Washington Post
Powered by NewsLook.com
Investigation Finds Hurt Workers Suffer More In Some States

Investigation Finds Hurt Workers Suffer More In Some States

Newsy (Mar. 4, 2015) ProPublica and NPR&apos;s joint investigation found drastic cuts to workers compensation benefits and employees&apos; access to those benefits. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins