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Hopes for reversing age-associated effects in MS patients

Date:
January 12, 2012
Source:
University of Cambridge
Summary:
New research highlights the possibility of reversing aging in the central nervous system for multiple sclerosis patients.

A proof of principle study suggests the age-associated decline of the remyelination process is reversible.
Credit: Image courtesy of University of Cambridge

New research highlights the possibility of reversing ageing in the central nervous system for multiple sclerosis (MS) patients. The study is published on January 6, in the journal Cell Stem Cell.

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As we get older, our bodies' ability to regenerate decreases. This is not only true for our skin (which is evident in the wrinkles that develop as we age) but also true for other tissues in the body, including the regenerative processes in the brain. For diseases which often span several decades and are affected by regenerative processes, such as multiple sclerosis, this can have massive implications.

In multiple sclerosis, the insulating layers that protect nerve fibres in the brain, known as myelin sheaths, become damaged. The loss of myelin in the brain prevents nerve fibres from sending signals properly and will eventually lead to the loss of the nerve fibre itself. However, early in the disease, a regenerative process, or remyelination, occurs and the myelin sheaths are restored. Unfortunately, as people with MS age, remyelination decreases significantly, resulting in more nerve fibres being permanently lost.

However, a new study in mice shows that the age-associated decline in the regeneration of the nerve's myelin sheath, or remyelination, is reversible. The proof of principle study demonstrates that when old mice are exposed to the inflammatory cells (called monocytes) from young mice, the ageing remyelination process can be reversed.

Professor Robin Franklin, Director of the MS Society's Cambridge Centre for Myelin Repair at the University of Cambridge, said: "What we have shown in our study, carried out in collaboration with Dr Amy Wagers and colleagues at Harvard University, is that the age-associated decline in remyelination is reversible. We found that remyelination in old adult mice can be made to work as efficiently as it does in young adult mice.

"For individuals with MS, this means that in theory regenerative therapies will work throughout the duration of the disease. Specifically, it means that remyelination therapies do not need to be based on stem cell transplantation since the stem cells already present in the brain and spinal cord can be made to regenerate myelin -- regardless of the patient's age."

Dr Doug Brown, Head of Biomedical Research at the MS Society said: "We've invested heavily in myelin repair research and are pleased to see key discoveries such as this being made as a result.

"Professor Franklin and his team have made significant breakthroughs in recent years and this provides more encouraging progress in their tireless effort to develop therapies that might stop or reverse the devastating effects of MS."

MS affects approximately 100,000 people in the United Kingdom, 400,000 in the United States and several million worldwide. Symptoms of the disease can include the loss of physical skills, sensation, vision, bladder control, and intellectual abilities.

This work is licensed under a Creative Commons Licence.


Story Source:

The above story is based on materials provided by University of Cambridge. The original story is licensed under a Creative Commons license. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julia M. Ruckh, Jing-Wei Zhao, Jennifer L. Shadrach, Peter van Wijngaarden, Tata Nageswara Rao, Amy J. Wagers, Robin J.M. Franklin. Rejuvenation of Regeneration in the Aging Central Nervous System. Cell Stem Cell, 2012; 10 (1): 96 DOI: 10.1016/j.stem.2011.11.019

Cite This Page:

University of Cambridge. "Hopes for reversing age-associated effects in MS patients." ScienceDaily. ScienceDaily, 12 January 2012. <www.sciencedaily.com/releases/2012/01/120106130332.htm>.
University of Cambridge. (2012, January 12). Hopes for reversing age-associated effects in MS patients. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/01/120106130332.htm
University of Cambridge. "Hopes for reversing age-associated effects in MS patients." ScienceDaily. www.sciencedaily.com/releases/2012/01/120106130332.htm (accessed November 28, 2014).

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