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Radiation-induced damage to brain tissue reversed by oxygen starvation in mice

Date:
January 18, 2012
Source:
Public Library of Science
Summary:
Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation.
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Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation. The results are reported in the Jan. 18 issue of the online journal PLoS ONE.

The researchers, led by William Sonntag of University of Oklahoma, exposed the mice to a clinically relevant regimen of radiation, which caused progressive deterioration of spatial learning starting about two months post-radiation.

However, when mice were treated with chronic hypoxia for about three weeks, beginning one month after radiation exposure, they showed significant improvement in this area, which was maintained for at least two months after returning to normal oxygen levels.

The radiation treatment also caused an early decline in contextual learning and memory, but these deficiencies were transient and dissipated within three months post-radiation.


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The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Junie P. Warrington, Anna Csiszar, Matthew Mitschelen, Yong Woo Lee, William E. Sonntag. Whole Brain Radiation-Induced Impairments in Learning and Memory Are Time-Sensitive and Reversible by Systemic Hypoxia. PLoS ONE, 2012; 7 (1): e30444 DOI: 10.1371/journal.pone.0030444

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Public Library of Science. "Radiation-induced damage to brain tissue reversed by oxygen starvation in mice." ScienceDaily. ScienceDaily, 18 January 2012. <www.sciencedaily.com/releases/2012/01/120118173651.htm>.
Public Library of Science. (2012, January 18). Radiation-induced damage to brain tissue reversed by oxygen starvation in mice. ScienceDaily. Retrieved May 29, 2015 from www.sciencedaily.com/releases/2012/01/120118173651.htm
Public Library of Science. "Radiation-induced damage to brain tissue reversed by oxygen starvation in mice." ScienceDaily. www.sciencedaily.com/releases/2012/01/120118173651.htm (accessed May 29, 2015).

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