Feb. 29, 2012 Scientists at University College Dublin have discovered a new way of measuring the potential success rate of an embryo before it is transferred back into the womb during in vitro fertilisation (IVF).
According to the findings published online in the journal Fertility and Sterility, the fluid within a woman's ovaries that surrounds the egg or oocyte holds metabolic information that can improve predictions on which embryo is more likely to lead to pregnancy.
"We analysed samples of the follicular fluid surrounding the immature ovum or egg before it was retrieved for IVF," says Dr Lorraine Brennan, UCD Conway Institute, University College Dublin, Ireland.
"We identified clear metabolic differences between the follicular fluids from women who successfully achieved pregnancy as a result of IVF to the fluids from the women who did not."
"Before the test can be regularised for use during IVF, our results need to be validated across a larger cohort of women undergoing treatment, and we are hopeful that the results obtained from larger samples will support our initial findings," says Dr Brennan.
Today, approximately 32% of IVF cycles result in pregnancy, so the standard procedure involves the transfer of multiple embryos back into the womb to increase the potential success rate.
But when more than one embryo is transferred back, there is an increased chance of multiple births like twins and triplets. There are increased health risks associated with multiple pregnancies for both mother and infants including an increased risk of miscarriages and preterm labour, leading to premature infants with admission to neonatal intensive care.
"In more recent years there has been an increase in the number of single embryo transfer (SET) as an effective way of reducing potential multiple births, but the widespread acceptance of SET is limited because there is no fully accurate method of embryo assessment and selection for transfer during IVF cycles."
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- Martina Wallace, Evelyn Cottell, Michael J. Gibney, Fionnuala M. McAuliffe, Mary Wingfield, Lorraine Brennan. An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome. Fertility and Sterility, 2012; DOI: 10.1016/j.fertnstert.2012.01.122
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