Featured Research

from universities, journals, and other organizations

Obstructive sleep apnea's damage evident after one month

Date:
April 23, 2012
Source:
American Physiological Society (APS)
Summary:
Obstructive sleep apnea (OSA) affects some 1 in 5 US adults. A novel research model finds after just 30 days of OSA exposure, cerebral vessel function is altered, which could lead to stroke.

Obstructive sleep apnea (OSA) is a disorder in which there are recurring episodes of upper airway collapse during sleep with ongoing effort to breathe. OSA is estimated to affect 1 in 5 adults in America. The serious nature of the problem was captured in a landmark study which found that middle-age and older men with even mild levels of OSA were in danger of increased risk of stroke and death. While a link between OSA and stroke is clear, OSA's effect on the cerebral (brain) vessels is not. In an effort to shed light on this relationship, researchers in Texas have developed a novel model that mimics OSA in humans. Their model has found that after just 30 days of OSA exposure cerebral vessel function is altered, which could lead to stroke.

The model and its findings are the result of efforts undertaken by Randy F. Crossland, David J. Durgan, Eric E. Lloyd, Sharon C. Phillips, Sean P. Marrelli and Robert M. Bryan, Baylor College of Medicine, Houston, Tex. An abstract of their study entitled, "Cerebrovascular Consequences of Obstructive Sleep Apnea," will be discussed at the meeting Experimental Biology 2012 being held April 21-25 at the San Diego Convention Center. The abstract is sponsored by the American Physiological Society (APS), one of six scientific societies sponsoring the conference which last year attracted some 14,000 attendees.

New Model, New Findings

The most common animal model used to study OSA today is intermittent hypoxia (IH) which relies solely on exposing animals to a decrease in blood oxygen levels. The new model incorporates all physiological consequences involved in OSA by inducing true apnea (closure of the airway). The revised model creates a more complete picture of the apnea process and one that more accurately mimics how OSA unfolds in humans.

Using their model the researchers induced 30 apneas (10 seconds duration) per hour in animals for 8-hours during the sleep cycle for up to one month. After one month of apnea, cerebral vessel dilatory function was reduced by up to 22 percent. This finding correlates with studies that show similar cell dysfunction in arteries and an increased risk of stroke in OSA patients. Damage to the vascular wall in brain arteries could be a factor predisposing an individual with OSA to stroke.

"There are two important findings in these results," according to researcher Randy Crossland. "The first is the model itself. The new model allows us to study the complete disease and better understand how repetitive exposure to apnea affects the body. The second is that only one month of moderate OSA produces altered cerebrovascular function which could result in a stroke. A finding that highlights the detrimental impact OSA can have on the body."

OSA Prevalence Expected to Rise

According to Mr. Crossland, some researchers estimate that up to 85 percent of patients with clinically significant sleep apnea have not been diagnosed. Obesity and aging are strongly associated with OSA. "As the prevalence of obesity is rising, and the population continues aging, we expect the rates of OSA to rise. It should also be noted that non-obese individuals and even children can have OSA," he said. And while OSA is seen more often in men than in women for unknown reasons some researchers believe that the true rate in females has been underestimated.

The common signs and symptoms of OSA include: habitual snoring, daytime sleepiness, enlarged neck size, morning headache, sexual dysfunction, and mood and behavioral changes. "OSA can have a detrimental impact on a person's body and their life. It is a serious, yet treatable, disorder that should not be taken lightly," according to Mr. Crossland.


Story Source:

The above story is based on materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society (APS). "Obstructive sleep apnea's damage evident after one month." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423131756.htm>.
American Physiological Society (APS). (2012, April 23). Obstructive sleep apnea's damage evident after one month. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2012/04/120423131756.htm
American Physiological Society (APS). "Obstructive sleep apnea's damage evident after one month." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423131756.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins