Featured Research

from universities, journals, and other organizations

Obstructive sleep apnea's damage evident after one month

Date:
April 23, 2012
Source:
American Physiological Society (APS)
Summary:
Obstructive sleep apnea (OSA) affects some 1 in 5 US adults. A novel research model finds after just 30 days of OSA exposure, cerebral vessel function is altered, which could lead to stroke.

Obstructive sleep apnea (OSA) is a disorder in which there are recurring episodes of upper airway collapse during sleep with ongoing effort to breathe. OSA is estimated to affect 1 in 5 adults in America. The serious nature of the problem was captured in a landmark study which found that middle-age and older men with even mild levels of OSA were in danger of increased risk of stroke and death. While a link between OSA and stroke is clear, OSA's effect on the cerebral (brain) vessels is not. In an effort to shed light on this relationship, researchers in Texas have developed a novel model that mimics OSA in humans. Their model has found that after just 30 days of OSA exposure cerebral vessel function is altered, which could lead to stroke.

The model and its findings are the result of efforts undertaken by Randy F. Crossland, David J. Durgan, Eric E. Lloyd, Sharon C. Phillips, Sean P. Marrelli and Robert M. Bryan, Baylor College of Medicine, Houston, Tex. An abstract of their study entitled, "Cerebrovascular Consequences of Obstructive Sleep Apnea," will be discussed at the meeting Experimental Biology 2012 being held April 21-25 at the San Diego Convention Center. The abstract is sponsored by the American Physiological Society (APS), one of six scientific societies sponsoring the conference which last year attracted some 14,000 attendees.

New Model, New Findings

The most common animal model used to study OSA today is intermittent hypoxia (IH) which relies solely on exposing animals to a decrease in blood oxygen levels. The new model incorporates all physiological consequences involved in OSA by inducing true apnea (closure of the airway). The revised model creates a more complete picture of the apnea process and one that more accurately mimics how OSA unfolds in humans.

Using their model the researchers induced 30 apneas (10 seconds duration) per hour in animals for 8-hours during the sleep cycle for up to one month. After one month of apnea, cerebral vessel dilatory function was reduced by up to 22 percent. This finding correlates with studies that show similar cell dysfunction in arteries and an increased risk of stroke in OSA patients. Damage to the vascular wall in brain arteries could be a factor predisposing an individual with OSA to stroke.

"There are two important findings in these results," according to researcher Randy Crossland. "The first is the model itself. The new model allows us to study the complete disease and better understand how repetitive exposure to apnea affects the body. The second is that only one month of moderate OSA produces altered cerebrovascular function which could result in a stroke. A finding that highlights the detrimental impact OSA can have on the body."

OSA Prevalence Expected to Rise

According to Mr. Crossland, some researchers estimate that up to 85 percent of patients with clinically significant sleep apnea have not been diagnosed. Obesity and aging are strongly associated with OSA. "As the prevalence of obesity is rising, and the population continues aging, we expect the rates of OSA to rise. It should also be noted that non-obese individuals and even children can have OSA," he said. And while OSA is seen more often in men than in women for unknown reasons some researchers believe that the true rate in females has been underestimated.

The common signs and symptoms of OSA include: habitual snoring, daytime sleepiness, enlarged neck size, morning headache, sexual dysfunction, and mood and behavioral changes. "OSA can have a detrimental impact on a person's body and their life. It is a serious, yet treatable, disorder that should not be taken lightly," according to Mr. Crossland.


Story Source:

The above story is based on materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.


Cite This Page:

American Physiological Society (APS). "Obstructive sleep apnea's damage evident after one month." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423131756.htm>.
American Physiological Society (APS). (2012, April 23). Obstructive sleep apnea's damage evident after one month. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/04/120423131756.htm
American Physiological Society (APS). "Obstructive sleep apnea's damage evident after one month." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423131756.htm (accessed September 16, 2014).

Share This



More Mind & Brain News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
'Fat Shaming' Might Actually Cause Weight Gain

'Fat Shaming' Might Actually Cause Weight Gain

Newsy (Sep. 11, 2014) A study for University College London suggests obese people who are discriminated against gain more weight than those who are not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins