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Immune system may protect against Alzheimer's changes in humans

Date:
May 25, 2012
Source:
University of Exeter
Summary:
Recent work in mice suggested that the immune system is involved in removing beta-amyloid, the main Alzheimer's-causing substance in the brain. Researchers have now shown for the first time that this may apply in humans. Researchers screened the expression levels of thousands of genes in blood samples from nearly 700 people. The telltale marker of immune system activity against beta-amyloid, a gene called CCR2, emerged as the top marker associated with memory in people.

Recent work in mice suggested that the immune system is involved in removing beta-amyloid, the main Alzheimer's-causing substance in the brain. Researchers have now shown for the first time that this may apply in humans.
Credit: Alexey Klementiev / Fotolia

Recent work in mice suggested that the immune system is involved in removing beta-amyloid, the main Alzheimer's-causing substance in the brain. Researchers have now shown for the first time that this may apply in humans.

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Researchers at the Peninsula College of Medicine and Dentistry, University of Exeter with colleagues in the National Institute on Aging in the USA and in Italy screened the expression levels of thousands of genes in blood samples from nearly 700 people. The telltale marker of immune system activity against beta-amyloid, a gene called CCR2, emerged as the top marker associated with memory in people.

The team used a common clinical measure called the Mini Mental State Examination to measure memory and other cognitive functions.

The previous work in mice showed that augmenting the CCR2-activated part of the immune system in the blood stream resulted in improved memory and functioning in mice susceptible to Alzheimer's disease.

Professor David Melzer, who led the work, commented: "This is a very exciting result. It may be that CCR2-associated immunity could be strengthened in humans to slow Alzheimer's disease, but much more work will be needed to ensure that this approach is safe and effective."

Dr Lorna Harries, co-author, commented: "Identification of a key player in the interface between immune function and cognitive ability may help us to gain a better understanding of the disease processes involved in Alzheimer's disease and related disorders."

Alzheimer's disease is the most common form of dementia and affects around 496,000 people in the UK.


Story Source:

The above story is based on materials provided by University of Exeter. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lorna W. Harries, Rachel M. Bradley-Smith, David J. Llewellyn, Luke C. Pilling, Alexander Fellows, William Henley, Dena Hernandez, Jack M. Guralnik, Stefania Bandinelli, Andrew Singleton, Luigi Ferrucci, David Melzer. LeukocyteCCR2Expression Is Associated with Mini-Mental State Examination Score in Older Adults. Rejuvenation Research, 2012; 120518094735004 DOI: 10.1089/rej.2011.1302

Cite This Page:

University of Exeter. "Immune system may protect against Alzheimer's changes in humans." ScienceDaily. ScienceDaily, 25 May 2012. <www.sciencedaily.com/releases/2012/05/120525103917.htm>.
University of Exeter. (2012, May 25). Immune system may protect against Alzheimer's changes in humans. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2012/05/120525103917.htm
University of Exeter. "Immune system may protect against Alzheimer's changes in humans." ScienceDaily. www.sciencedaily.com/releases/2012/05/120525103917.htm (accessed February 1, 2015).

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