Featured Research

from universities, journals, and other organizations

Intravenous kidney cell transplant experiments raise hope for future human kidney failure treatments

Date:
May 31, 2012
Source:
Indiana University School of Medicine
Summary:
Scientists have successfully transplanted primary kidney cells intravenously to treat renal failure in rats, pointing the way to a possible future alternative to kidney transplants and expensive dialysis treatments in humans.

Indiana University School of Medicine scientists have successfully transplanted primary kidney cells intravenously to treat renal failure in rats, pointing the way to a possible future alternative to kidney transplants and expensive dialysis treatments in humans.

The researchers, Katherine J. Kelly, M.D., associate professor of medicine, and Jesus Dominguez, M.D., professor of medicine, genetically modified the cells in the laboratory to produce a protein -- called SAA -- that plays an important role in renal cell growth, embryonic kidney development and kidney regeneration after an injury. Modified cells found their way to the appropriate locations of the damaged kidneys, resulting in regeneration of tissue and improved function in the kidney.

The researchers' work has been accepted for publication in the American Journal of Physiology -- Renal Physiology, which published an advance online version of the paper on May 16.

The authors point out there is a significant and expanding need for better kidney treatments because growing numbers of people are facing progressive kidney failure due to rising incidence of diabetes, hypertension and the aging of the population.

According to the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, more than 20 million Americans have chronic kidney disease, and more than half a million people are being treated for end stage renal disease. For those patients the options are limited to dialysis or kidney transplants. Nearly 99,000 people are now on the waiting list for a kidney transplant, according to the Organ Procurement and Transplantation Network, and more than 12 people die each day while on a kidney transplant waiting list.

"Obviously there is a need for, and an opportunity for, regenerative medicine in kidney failure as well as other organs," said Dr. Dominguez. There have been efforts to use stem cells to regenerate kidney tissue, but the benefits have not been long lasting, he noted.

In the IU researchers' experiments, however, some of the reprogrammed adult kidney donor cells made their way back to the damaged rat kidneys and engrafted themselves into key locations for renal function, resulting in improved kidney function and limiting physical damage. In some cases the modified cells came from other donor rats. In other experiments, one of the rats damaged kidneys was removed and the treated cells were grown in the laboratory and then returned to the same rat.

"Ultimately, you can imagine taking a part of someone's kidney, expanding those cells with appropriate growth factors in a tissue culture dish, and then giving the cells back," said Dr. Kelly.

The researchers cautioned, however, that much work remains to be done before tests could begin in humans.

The research was supported in part with funds from the National Institutes of Health to Dr. Kelly (Grant no. 5R01DK082739) and the Veterans Administration Merit Review program to Dr. Dominguez.


Story Source:

The above story is based on materials provided by Indiana University School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. J. Kelly, J. Zhang, M. Wang, S. Zhang, J. H. Dominguez. Intravenous Renal Cell Transplantation (IRCT) for rats with acute and chronic renal failure. AJP: Renal Physiology, 2012; DOI: 10.1152/ajprenal.00680.2011

Cite This Page:

Indiana University School of Medicine. "Intravenous kidney cell transplant experiments raise hope for future human kidney failure treatments." ScienceDaily. ScienceDaily, 31 May 2012. <www.sciencedaily.com/releases/2012/05/120531135645.htm>.
Indiana University School of Medicine. (2012, May 31). Intravenous kidney cell transplant experiments raise hope for future human kidney failure treatments. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/05/120531135645.htm
Indiana University School of Medicine. "Intravenous kidney cell transplant experiments raise hope for future human kidney failure treatments." ScienceDaily. www.sciencedaily.com/releases/2012/05/120531135645.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins