Featured Research

from universities, journals, and other organizations

Nanoparticles hold promise to improve blood cancer treatment

Date:
June 15, 2012
Source:
University of Notre Dame
Summary:
Researchers have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.

Researchers from the University of Notre Dame have engineered nanoparticles that show great promise for the treatment of multiple myeloma (MM), an incurable cancer of the plasma cells in bone marrow.

One of the difficulties doctors face in treating MM comes from the fact that cancer cells of this type start to develop resistance to the leading chemotherapeutic treatment, doxorubicin, when they adhere to tissue in bone marrow.

"The nanoparticles we have designed accomplish many things at once," says Başar Bilgiηer, assistant professor of chemical and biomolecular engineering and chemistry and biochemistry, and an investigator in Notre Dame's Advanced Diagnostics and Therapeutics (AD&T) initiative.

"First, they reduce the development of resistance to doxorubicin. Second, they actually get the cancer cells to actively consume the drug-loaded nanoparticles. Third, they reduce the toxic effect the drug has on healthy organs."

The nanoparticles are coated with a special peptide that targets a specific receptor on the outside of multiple myeloma cells. These receptors cause the cells to adhere to bone marrow tissue and turn on the drug resistance mechanisms. But through the use of the newly developed peptide, the nanoparticles are able to bind to the receptors instead and prevent the cancer cells from adhering to the bone marrow in the first place.

The particles also carry the chemotherapeutic drug with them. When a particle attaches itself to an MM cell, the cell rapidly takes up the nanoparticle, and only then is the drug released, causing the DNA of cancer cell to break apart and the cell to die.

"Our research on mice shows that the nanoparticle formulation reduces the toxic effect doxorubicin has on other tissues, such as the kidneys and liver," adds Tanyel Kiziltepe, a research assistant professor with the Department of Chemical and Biomolecular Engineering and AD&T.

"We believe further research will show that the heart is less affected as well. This could greatly reduce the harmful side-effects of this chemotherapy."

The group had to tackle three important problems associated with all nanoparticle-based therapies, explains Jonathan Ashley, one of the leading researchers of the project.

"There was some complex bioengineering involved in developing the particles. We were able to precisely control the number of drug and targeting elements on each nanoparticle, achieve homogeneous nanoparticle size distribution and eliminate the batch-to-batch variability in particle production."

Before advancing to human clinical trials, the team plans further research and testing to improve the design of the nanoparticles and to find the optimum amount and combination of chemotherapy drugs for this new treatment.

The research is described in greater detail in a recent edition of Nature's Blood Cancer Journal. It was supported by funding from the Indiana Clinical and Translational Sciences Institute.


Story Source:

The above story is based on materials provided by University of Notre Dame. Note: Materials may be edited for content and length.


Journal Reference:

  1. T Kiziltepe, J D Ashley, J F Stefanick, Y M Qi, N J Alves, M W Handlogten, M A Suckow, R M Navari, B Bilgicer. Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo. Blood Cancer Journal, 2012; 2 (4): e64 DOI: 10.1038/bcj.2012.10

Cite This Page:

University of Notre Dame. "Nanoparticles hold promise to improve blood cancer treatment." ScienceDaily. ScienceDaily, 15 June 2012. <www.sciencedaily.com/releases/2012/06/120615204741.htm>.
University of Notre Dame. (2012, June 15). Nanoparticles hold promise to improve blood cancer treatment. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2012/06/120615204741.htm
University of Notre Dame. "Nanoparticles hold promise to improve blood cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2012/06/120615204741.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) — Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) — A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) — More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins