Featured Research

from universities, journals, and other organizations

Single dose radiation at time of surgery helps women with early stage breast cancer forego 6-7 week radiation regimen

Date:
July 5, 2012
Source:
NewYork-Presbyterian Hospital/Columbia University Medical Center and NewYork-Presbyterian Hospital/W
Summary:
INTRABEAM radiotherapy is an innovative radiation treatment delivered in a single dose at the time of surgery.

NewYork-Presbyterian Hospital/Weill Cornell Medical Center is the first and only hospital in the five boroughs of New York City to offer women with early stage breast cancer INTRABEAM radiotherapy, an innovative radiation treatment delivered in a single dose at the time of surgery.

Women with early stage breast cancer often have breast-conserving surgery, otherwise known as a lumpectomy, to remove a cancerous tumor. Lumpectomy is followed by a regimen of daily doses of radiation therapy to the entire breast, generally lasting six to seven consecutive weeks.

"INTRABEAM Radiotherapy may be an effective alternative to a six to seven week regimen following surgery for select patients because it allows us to precisely target any remaining cancer cells right inside the tumor bed, where the tumor is most likely to recur," says Dr. Mary Katherine Hayes, clinical director of Radiation Oncology at NewYork-Presbyterian Hospital/Weill Cornell Medical Center and associate professor of Clinical Radiology and Radiation Oncology at Weill Cornell Medical College.

Immediately following removal of the tumor, while the patient is still on the operating table, the INTRABEAM applicator's small, cylindrical tip is placed inside the tumor cavity to deliver a superficial dose of radiation for 20-30 minutes, while limiting exposure to healthy surrounding tissue and organs. After the applicator is removed, the surgical incision is closed.

"Our ability to use this radiation technique in such a timely manner may add to its effectiveness since the area in need of treatment can be directly visualized at the moment the tumor is removed," say Dr. Alexander J. Swistel, attending breast surgeon at the Iris Cantor Women's Health Center at NewYork-Presbyterian/Weill Cornell Medical Center and associate professor of clinical surgery at Weill Cornell Medical College.

This alternative to conventional full-breast radiation therapy is in step with the hospital's longstanding practice of tailoring partial breast cancer treatments to a growing number of patients with a small, early stage tumor. Eliminating an additional 6-7 weeks of radiation therapy is particularly convenient for patients who do not live in close proximity to a hospital or an established radiation therapy facility.

A 10-year randomized phase 3 clinical trial of intraoperative therapy for breast cancer found that for selected patients, single dose radiotherapy delivered at the time of surgery yielded the same results as conventional full breast radiation delivered over several weeks. The TARGIT-A Trial, published in The Lancet in July 2010, studied only the INTRABEAM system and was the largest randomized clinical trial conducted in this field, more than two thousand women in multiple countries were enrolled.

While INTRABEAM is limited to a select group of patients with a very small tumor, if tissue samples removed during surgery prove more aggressive than preliminary tests revealed, the patient will still be able to undergo conventional full-breast radiation. However, the patient would not need to undergo the final five-day phase of conventional treatment, known as boost therapy, which targets the tumor bed with external radiation.


Story Source:

The above story is based on materials provided by NewYork-Presbyterian Hospital/Columbia University Medical Center and NewYork-Presbyterian Hospital/W. Note: Materials may be edited for content and length.


Cite This Page:

NewYork-Presbyterian Hospital/Columbia University Medical Center and NewYork-Presbyterian Hospital/W. "Single dose radiation at time of surgery helps women with early stage breast cancer forego 6-7 week radiation regimen." ScienceDaily. ScienceDaily, 5 July 2012. <www.sciencedaily.com/releases/2012/07/120705171944.htm>.
NewYork-Presbyterian Hospital/Columbia University Medical Center and NewYork-Presbyterian Hospital/W. (2012, July 5). Single dose radiation at time of surgery helps women with early stage breast cancer forego 6-7 week radiation regimen. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/07/120705171944.htm
NewYork-Presbyterian Hospital/Columbia University Medical Center and NewYork-Presbyterian Hospital/W. "Single dose radiation at time of surgery helps women with early stage breast cancer forego 6-7 week radiation regimen." ScienceDaily. www.sciencedaily.com/releases/2012/07/120705171944.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins