Featured Research

from universities, journals, and other organizations

New technique identifies cellular 'Needle in a haystack'

Date:
July 11, 2012
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Rare cells can be identified within mixed cell populations with near perfect accuracy using a new detection technique. This technique may facilitate cancer diagnosis, which often relies on the detection of rare cancerous cells in tiny amounts of biopsy tissue or fluid.

Rare cells can be identified within mixed cell populations with near perfect accuracy using a detection technique devised by research teams led by Robert Wieder, MD, PhD, at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School and Rajan Kumar, MD, PhD, at Genome Data Systems in Hamilton, N.J. This technique may facilitate cancer diagnosis, which often relies on the detection of rare cancerous cells in tiny amounts of biopsy tissue or fluid.

Wieder's group previously described this approach, which employs microfluidics, in which cells expressing a specific surface protein are identified as they are pumped through a narrow fluid channel. The channel is coated with a binding partner for the protein of interest, slowing the progress of the cells of interest while allowing non-specific cells to pass through unhindered.

In the new study, published in the Royal Society of Chemistry journal Lab on a Chip, the group optimized the assay to allow the detection of rare breast cancer cells in a mixed population with 100% sensitivity and specificity and without prior manipulation. The process left the cells undamaged, making them available for additional microfluidic, cellular or molecular testing, including analysis of surface proteins known to affect prognosis or response to treatment in patients with cancer, infectious or inflammatory diseases or exposure to toxins.

The University of Medicine and Dentistry of New Jersey (UMDNJ) is New Jersey's only health sciences university with more than 6,000 students on five campuses attending three medical schools, the State's only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and New Jersey's only school of public health. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, which provides a continuum of healthcare services with multiple locations throughout the State.


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. Kumar R, Vellanki SH, Smith R, Wieder R. Determination of single cell surface protein expression using a tagless microfluidic method. Lab Chip, 2012 May 7;12(9):1646-55 [link]

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "New technique identifies cellular 'Needle in a haystack'." ScienceDaily. ScienceDaily, 11 July 2012. <www.sciencedaily.com/releases/2012/07/120711111403.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2012, July 11). New technique identifies cellular 'Needle in a haystack'. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2012/07/120711111403.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "New technique identifies cellular 'Needle in a haystack'." ScienceDaily. www.sciencedaily.com/releases/2012/07/120711111403.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins