Featured Research

from universities, journals, and other organizations

Measuring HDL particles as opposed to HDL cholesterol is a a better indicator of coronary heart disease, study suggests

Date:
July 11, 2012
Source:
Brigham and Women's Hospital
Summary:
Researchers have discovered that measuring HDL particles as opposed to HDL cholesterol is a much better indicator of coronary heart disease.

Until recently, it seemed well-established that high-density lipoprotein (HDL) is the "good cholesterol." However there are many unanswered questions on whether raising someone's HDL can prevent coronary heart disease, and on whether or not HDL still matters. A team of researchers at Brigham and Women's Hospital (BWH), the University of Pittsburgh Graduate School of Public Health (GSPH) and other institutions, have discovered that measuring HDL particles (HDL-P) as opposed to HDL cholesterol (HDL-C) is a much better indicator of coronary heart disease (CHD), and that HDL does indeed, still matter.

Related Articles


This study will be electronically published July 11, 2012 and will be published in the August 7th print issue of the Journal of American College of Cardiology.

"Several recent failures of HDL-raising drugs and a genetic study have generated doubt that circulating levels of HDL in the blood are causally related to heart disease, and that raising HDL is a promising therapeutic approach," said Rachel Mackey, PhD, principal investigator of the study and assistant professor of epidemiology at GSPH.

Most previous studies of HDL have looked at the cholesterol to assess CHD risk, not many have examined the particle count. The research team analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA), an NIH funded multiethnic study. The researchers focused on a subset of data of 5,500 middle-aged men and women, over the age of 45. They looked at the quantity of HDL particles (HDL-P) in addition to the quantity of cholesterol carried by the particles (HDL-C), which has historically been used to measure HDL.

"HDL cholesterol is only one property of HDL particles -- it's like cargo on a ship, one can look at HDL cholesterol, which is one type of the cargo that is carried on the ship, or one can look at the number of ships. In our study, we found that the number of HDL particles had stronger cardio-protection than HDL cholesterol," explained Samia Mora, MD, a physician in the Cardiovascular and Preventive Divisions at BWH and senior author on the study.

The study suggests that it's important to not only measure HDL cholesterol, but to experiment with other ways of measurement, such as HDL particles. "Before we lose confidence in the potential of raising HDL to benefit patients, there needs to be more research extending beyond HDL cholesterol measurement," Explained Dr. Mackey.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Emil M. deGoma, Daniel J. Rader. High-Density Lipoprotein Particle Number. Journal of the American College of Cardiology, 2012; DOI: 10.1016/j.jacc.2012.03.058

Cite This Page:

Brigham and Women's Hospital. "Measuring HDL particles as opposed to HDL cholesterol is a a better indicator of coronary heart disease, study suggests." ScienceDaily. ScienceDaily, 11 July 2012. <www.sciencedaily.com/releases/2012/07/120711210058.htm>.
Brigham and Women's Hospital. (2012, July 11). Measuring HDL particles as opposed to HDL cholesterol is a a better indicator of coronary heart disease, study suggests. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/07/120711210058.htm
Brigham and Women's Hospital. "Measuring HDL particles as opposed to HDL cholesterol is a a better indicator of coronary heart disease, study suggests." ScienceDaily. www.sciencedaily.com/releases/2012/07/120711210058.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins