Featured Research

from universities, journals, and other organizations

Brain activity changes may reduce risk of Alzheimer's

Date:
July 15, 2012
Source:
Mayo Clinic
Summary:
Activity lingers longer in certain areas of the brain in those with Alzheimer’s than it does in healthy people, researchers who created a map of the brain found. The results suggest varying brain activity may reduce the risk of Alzheimer’s disease.

Activity lingers longer in certain areas of the brain in those with Alzheimer's than it does in healthy people, Mayo Clinic researchers who created a map of the brain found. The results suggest varying brain activity may reduce the risk of Alzheimer's disease. The study, "Non-stationarity in the "Resting Brain's" Modular Architecture," was presented at the Alzheimer's Association International Conference and recently published in the journal PLoS One.

Researchers compared brain activity to a complex network, with multiple objects sharing information along pathways.

"Our understanding of those objects and pathways is limited," says lead author David T. Jones, M.D. "There are regions in the brain that correspond to those objects, and we are not really clear exactly what those are. We need a good mapping or atlas of those regions that make up the network in the brain, which is part of what we were doing in this study."

Researchers examined 892 cognitively normal people taking part in the Mayo Clinic Study of Aging, and set out to create an active map of their brains while the people were "at rest," not engaged in a specific task. To do this, they employed task-free, functional magnetic resonance imaging to construct an atlas of 68 functional regions of the brain, which correspond to the cities on the road map.

Researchers filled in the roads between these regions by creating dynamic graphic representations of brain connectivity within a sliding time window.

This analysis revealed that there were many roads that could be used to exchange information in the brain, and the brain uses different roads at different times. The question to answer then, said Dr. Jones, is whether or not Alzheimer's patients used this map and these roads in a different way than their healthy peers.

"What we found in this study was that Alzheimer's patients tended to spend more time using some roads and less time using other roads, biasing one over the other," he says.

While more research is needed, the researchers say one implication is that how we use our brains may protect us from Alzheimer's. Dr. Jones says exercise, education, and social contacts may help balance activity in the brain.

"Diversifying the mental space that you explore may actually decrease your risk for Alzheimer's," he says.

This work was supported by the National Institute on Aging, the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation, and Alzheimer's Association New Investigator grant.

Co-authors include David T. Jones, M.D.; Prashanthi Vemuri, Ph.D.; Matthew C. Murphy, Ph.D.; Jeffrey L. Gunter, Ph.D.; Matthew L. Senjem; Mary M. Machulda, Ph.D.; Scott A. Przybelski; Brian E. Gregg; Kejal Kantarci,M.D.; David S. Knopman, M.D.; Bradley F. Boeve, M.D.; Ronald C. Petersen, M.D., Ph.D.; and Clifford R. Jack, Jr., M.D.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. David T. Jones, Prashanthi Vemuri, Matthew C. Murphy, Jeffrey L. Gunter, Matthew L. Senjem, Mary M. Machulda, Scott A. Przybelski, Brian E. Gregg, Kejal Kantarci, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Clifford R. Jack. Non-Stationarity in the “Resting Brain’s” Modular Architecture. PLoS ONE, 2012; 7 (6): e39731 DOI: 10.1371/journal.pone.0039731

Cite This Page:

Mayo Clinic. "Brain activity changes may reduce risk of Alzheimer's." ScienceDaily. ScienceDaily, 15 July 2012. <www.sciencedaily.com/releases/2012/07/120715121919.htm>.
Mayo Clinic. (2012, July 15). Brain activity changes may reduce risk of Alzheimer's. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/07/120715121919.htm
Mayo Clinic. "Brain activity changes may reduce risk of Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2012/07/120715121919.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins