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Most with celiac disease unaware of it; others go gluten-free without diagnosis

Date:
July 31, 2012
Source:
Mayo Clinic
Summary:
Roughly 1.8 million Americans have celiac disease, but around 1.4 million of them are unaware that they have it, a new analysis of the condition’s prevalence has found.

Roughly 1.8 million Americans have celiac disease, but around 1.4 million of them are unaware that they have it, a Mayo Clinic-led analysis of the condition's prevalence has found. Meanwhile, 1.6 million people in the United States are on a gluten-free diet even though they haven't been diagnosed with celiac disease, according to the study published July 31 in the American Journal of Gastroenterology.

Researchers have estimated the rate of diagnosed and undiagnosed celiac disease at similar levels prior to this study, but this is the most definitive study on the issue. "This provides proof that this disease is common in the United States," says co-author Joseph Murray, M.D., a Mayo Clinic gastroenterologist. "If you detect one person for every five or six (who have it), we aren't doing a very good job detecting celiac disease."

Celiac disease is a digestive disorder brought on when genetically susceptible people eat wheat, rye and barley. A gluten-free diet, which excludes the protein gluten, is used to treat celiac disease. Roughly 80 percent of the people on a gluten-free diet do so without a diagnosis of celiac disease.

"There are a lot of people on a gluten-free diet, and it's not clear what the medical need for that is," Dr. Murray says. "It is important if someone thinks they might have celiac disease that they be tested first before they go on the diet."

To determine its prevalence, researchers combined blood tests confirming celiac disease with interviews from a Centers for Disease Control and Prevention (CDC) nationwide population sample survey called National Health and Nutrition Examination Survey. The survey, designed to assess the health and nutrition of U.S. adults and children, is unique in that it combines interviews and physical examinations.

Researchers found that celiac disease is much more common in Caucasians.

"In fact, virtually all the individuals we found were non-Hispanic Caucasians," says co-author Alberto Rubio-Tapia, M.D., a Mayo Clinic gastroenterologist. But previous research in Mexico has shown that celiac disease could be just as common as it is in the U.S.

"So that is something we don't fully understand," Dr. Rubio-Tapia says. The study found the rate of celiac disease in the U.S. is similar to that found in several European countries.

The research was funded in part by the National Institutes of Health and the CDC. Study authors include James Everhart, M.D., from the National Institute of Diabetes and Digestive and Kidney Disease; Jonas Ludvigsson, M.D., Ph.D., from Orebro University Hospital and the Karolinska Institutet; and Tricia Brantner from Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alberto Rubio-Tapia, Jonas F Ludvigsson, Tricia L Brantner, Joseph A Murray, James E Everhart. The Prevalence of Celiac Disease in the United States. The American Journal of Gastroenterology, 2012; DOI: 10.1038/ajg.2012.219

Cite This Page:

Mayo Clinic. "Most with celiac disease unaware of it; others go gluten-free without diagnosis." ScienceDaily. ScienceDaily, 31 July 2012. <www.sciencedaily.com/releases/2012/07/120731094104.htm>.
Mayo Clinic. (2012, July 31). Most with celiac disease unaware of it; others go gluten-free without diagnosis. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2012/07/120731094104.htm
Mayo Clinic. "Most with celiac disease unaware of it; others go gluten-free without diagnosis." ScienceDaily. www.sciencedaily.com/releases/2012/07/120731094104.htm (accessed September 20, 2014).

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