Featured Research

from universities, journals, and other organizations

Cervical cancer and pre-cancer cervical growths require single HPV protein

Date:
September 17, 2012
Source:
University of Wisconsin-Madison
Summary:
Human papillomavirus (HPV) has long been implicated in cervical cancer, but details of how it happens have remained a mystery. Now researchers have found that a single HPV protein is required for cervical cancer and even pre-cancer growths in the cervix to survive.

Human papillomavirus (HPV) has long been implicated in cervical cancer, but details of how it happens have remained a mystery. Now researchers at the University of Wisconsin-Madison have found that a single HPV protein is required for cervical cancer and even pre-cancer growths in the cervix to survive.

In anticipation of a clinical trial in humans, the scientists and their collaborators are moving quickly to test if a gene-silencing technique could cripple the protein and eliminate cervical cancer and pre-cancerous growths in specially-bred mice.

The study, appearing online in Cancer Research, is the first to show that the protein works in living animals and in pre-cancerous growths as well as full-blown cervical cancer.

Cervical cancer is relatively rare in the United States, thanks to the widespread use of Pap smears as a screening tool. But pre-cancer lesions in the cervix, called cervical inter-epithelial neoplasias, or CINs, are common.

Low-grade CINs are typically left alone because most will shrink and pose no problem. But women with high-grade CINs have a 10 percent chance of getting cervical cancer, says Dr. Paul Lambert, senior author on the paper. In addition, surgical treatment of high-grade CINs carries a risk of excessive bleeding and even infertility.

Scientists know that two HPV cancer-causing proteins, or oncoproteins -- E6 and E7 -- are always expressed in cervical cancer. Lambert and his team at UW's McArdle Laboratory of Cancer Research conducted experiments in cultured cell lines that suggested that the oncoproteins caused cervical cancer as well as anal and head and neck cancers. The researchers also learned that E7 had a much greater ability than E6 to cause cancer.

Other studies in different types of cancers suggested that when oncoproteins were involved, they needed to work together--blocking the expression of both often led to a more effective reduction of tumors than blocking either one alone.

But Lambert, a member of the UW Carbone Cancer Center, was intrigued with E7's power.

"In thinking of treatments, we wondered in this case if we could target just one oncoprotein, the most potent one, rather than two, which could be much more complicated," he says.

Dr. Sean Jabbar and Soyeong Park in the Lambert laboratory created and bred mice in which they could control the expression of both E7 and E6. They found that when he turned off E7 but left E6 on, the cervical cancers and CINs melted away.

"This told us that E7 should be an excellent therapeutic target for HPV-associated cancers, including pre-cancerous CINs," Lambert says.

If the gene-silencing experiments that are expected to take place soon prove effective, there's a good chance that the blocking approach could be used to control the disease without surgery.

Women in developing countries might benefit greatly, Lambert adds.

"Cervical cancer is prevalent around the world in places where screening does not exist and surgery is not available," he says.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Journal Reference:

  1. M.-K. Shin, J. Sage, P. F. Lambert. Inactivating all three Rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Research, 2012; DOI: 10.1158/0008-5472.CAN-12-2083

Cite This Page:

University of Wisconsin-Madison. "Cervical cancer and pre-cancer cervical growths require single HPV protein." ScienceDaily. ScienceDaily, 17 September 2012. <www.sciencedaily.com/releases/2012/09/120917123856.htm>.
University of Wisconsin-Madison. (2012, September 17). Cervical cancer and pre-cancer cervical growths require single HPV protein. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/09/120917123856.htm
University of Wisconsin-Madison. "Cervical cancer and pre-cancer cervical growths require single HPV protein." ScienceDaily. www.sciencedaily.com/releases/2012/09/120917123856.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins